1. Title Chapter 13 Gene regulation

2. CO 13

3. Fig. 13.1

4. Fig. 13.3

5. Fig. 13.4

6. Fig. 13.4a

7. Fig. 13.4b

8. Fig. 13.5

9. Fig. 13.5a

10. Fig. 13.5b

11. Fig. 13.6

12. Fig. 13.6a

13. Fig. 13.6b

14. Fig. 13.7

15. Fig. 13.7a

16. Fig. 13.7b

17. Fig. 13.8

18. Fig. 13.8a

19. Fig. 13.8b

20. Fig. 13.9

21. Fig. 13.9-1

22. Fig. 13.9-2

23. Fig. 13.9-3

24. Fig. 13.9-4

25. Fig. 13.9-5

26. Fig. 13.9-6

27. Fig. 13.9-7

28. Fig. 13.10

29. Fig. 13.10-2

30. Fig. 13.11

31. Fig. 13.11a

32. Fig. 13.11b

33. Fig. 13.11c

34. Fig. 13.11d

35. Fig. 13.12 Repressible operon Anabolic enzyme corepressor

36. Fig. 13.12a

37. Fig. 13.12b

38. Fig. 13.13 Regulation of transcription in eukaryotes 3 features:1.2.3 1.2. 3. Basal transcription Some RE: Enhancers or silencers

39. Fig. 13.14 General transcription factors Core promoter

40. Fig. 13.15 1. Activators 2. repressors 3. compaction of DNA

41. Fig. 13.16 Gene accessibility is controlled by changes in chromatin structure Activators: Histone acetyltransferase (acetyl group, ---COCH3) ATP-dependent chromatin remodeling enzymes: to loosen the compaction of chromatin

42. Fig. 13.17 Steroid hormones exert their effects by binding to a regulatory transcription factors and controlling the transcription of near genes Nuclear localization signals Glucocorticoid response element

43. Fig. 13.18 Structure features of regulatory transcription factors allow them to bind to DNA

44. Fig. 13.18a

45. Fig. 13.18b

46. Fig. 13.18c

47. Fig. 13.18d

48. Page 272 DNA methylation inhibits gene transcription DNA methylase CpG island: near promoter 1.Prevent an activator binding 2.Inhibit open conformation:

49. Fig. 13.19 13.4 Regulation of RNA processing and translation in eukaryotes Alternative splicing of pre-mRNA: creats protein diversity.

50. Fig. 13.20 MicroRNAs inhibit mRNA by translastional repression or mRNA degradation Micro RNA: miRNA enzyme RNA-induced silencing complex(RISC) RNA interference (RNAi):

51. Fig. 13.21 Iron:vital and toxic  ferritin: store excess iron.

52. Fig. 13.21a

53. Fig. 13.21b