1. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 More Pow(d)er For You - Monetary advantages of die table segments !

2. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Die Table Segments NEW TECHNOLOGY

3. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Advantages of Die Table Segments  Increased output  Reduced number of turrets and parts  Reduced change over time  Reduced cleaning time  Less product loss  Reduced ejection force  Uniform hardness of shaped tablets  Longer life time

4. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  Increased number of stations per die table Advantages of Die Table Segments Increased output Advantages of Die Table Segments Increased output 25 % Up to 25 % more output OLD up to ø16 36 stations EU19 max. filling depth 18mm max. output: 248.400 tabl/h NEW ! up to ø18 45 stations EU19 max. filling depth 22mm max. output: 310.500 tabl/h

5. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  Increased number of stations per die table Advantages of Die Table Segments Increased output Advantages of Die Table Segments Increased output 25 % Up to 25 % more output

6. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  Only 1 segment turret instead of 3 turrets for the same production  BBS, BB, B: all 3 sizes can be run on one segment only by changing the segments Advantages of Die Table Segments Reduced number of parts Advantages of Die Table Segments Reduced number of parts Reduced equipment costs

7. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  No dies and die screws necessary Advantages of Die Table Segments Reduced number of parts Advantages of Die Table Segments Reduced number of parts

8. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  No dies and die screws necessary Advantages of Die Table Segments Reduced number of parts Advantages of Die Table Segments Reduced number of parts

9. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  No dies and die screws necessary  Only 3 segments for a 2090i instead of 47 dies + 47 die screws Advantages of Die Table Segments Reduced number of parts Advantages of Die Table Segments Reduced number of parts

10. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Advantages of Die Table Segments Reduced change over time Advantages of Die Table Segments Reduced change over time  Complete turret with segments  One die segment removed  Compatible to standard presses

11. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  No dies and die screws necessary  Many die screws replaced by 6 or 10 segment screws  Many dies replaced by few segments  Only 3 or 5 segments depending on tablet press type Advantages of Die Table Segments Reduced change over time Advantages of Die Table Segments Reduced change over time Extremely short change over time

12. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  Time consuming adjustment of dies to punches for special format tablets no longer required Advantages of Die Table Segments Reduced change over time Advantages of Die Table Segments Reduced change over time Maximised productivity

13. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Advantages of Die Table Segments Reduced change over time Advantages of Die Table Segments Reduced change over time  Easy segment fixing by 2 screws for every segment  Conventional with a 2090 i : loosening and removing 36 screws, removing 36 dies  Now: dismantling 6 clamping wedges and 6 screws, remove 3 die table segments  Only 9 manual actions instead of the conventional 72

14. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Advantages of Die Table Segments Reduced cleaning time Advantages of Die Table Segments Reduced cleaning time  No screw holes and no die bores  Fewer parts  Cleaning of a few (3 or 5) segments instead of many dies and die screws  No cleaning of screw bores  No cleaning of die seats 1.Step 2. Step

15. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Advantages of Die Table Segments Reduced cleaning time Advantages of Die Table Segments Reduced cleaning time  Screw holes and die bores DIE BORES SCREW HOLES

16. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Advantages of Die Table Segments Reduced cleaning time Advantages of Die Table Segments Reduced cleaning time  Nono  No die bores and no screw holes  Very easy and fast cleaning of die table segments

17. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  No screw holes and no die bores Advantages of Die Table Segments Reduced cleaning time Advantages of Die Table Segments Reduced cleaning time Cleaning work is significantly easier

18. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Advantages of Die Table Segments Less product loss Advantages of Die Table Segments Less product loss ROUGH EDGES

19. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 NO ROUGH EDGES Advantages of Die Table Segments Less product loss Advantages of Die Table Segments Less product loss

20. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 in comparison to NO ROUGH EDGESROUGH EDGES Advantages of Die Table Segments Less product loss Advantages of Die Table Segments Less product loss Decrease of product loss

21. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Advantages of Die Table Segments Less product loss Advantages of Die Table Segments Less product loss  No rough edges  Scraper slides over plane surface  Die table segments surfaces are smooth  No gaps between die table and dies Product loss reduced by more than 50%

22. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  Significant reduction in wall friction during tablet ejection due to hard segment with extremely smooth surface  Low wall friction during ejection minimizes loss of tablet hardness  Lower pressing forces are required  Longer lifetime as a result of reduced stress Advantages of Die Table Segments Reduced ejection force Advantages of Die Table Segments Reduced ejection force Longer lifetime

23. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Cavities are parallel orien- tated to the circumference. So hardness variation due to centrifugal force difference between in- and outside is reduced to the possible minimum. Advantages of Die Table Segments Uniform hardness of shaped tablets Advantages of Die Table Segments Uniform hardness of shaped tablets  Less variation in hardness of shaped tablets  Better hardness  More uniform fill  Better standard deviation

24. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  Replacement of dies held in position by die screws by clamped segments makes it possible to increase the bore hardness  Segments – like dies – can be used on both sides to extend timelife  Robust material reduces wear  Segments made of special high-alloy steel Advantages of Die Table Segments Longer Lifetime Advantages of Die Table Segments Longer Lifetime Longer lifetime Less wear and tear

25. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  Compatible with the PT/P and i generations  Also a huge increases in performance on presses of former generations  Available in AISI 316L for WiP presses Compatible with the PT/P and i generations Compatible with the PT/P and i generations

26. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Die Table Segments Increased output Additional profit & Cost saving Reduced number of parts Reduced change over time Reduced cleaning time Less product loss Longer lifetime

27. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Die Table Segments - More Pow(d)er For You - Monetary advantages of die table segments ! How is it possible to calculate the monetary advantages ? - More Pow(d)er For You - Monetary advantages of die table segments ! How is it possible to calculate the monetary advantages ?

28. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Monetary advantages of Die Table Segments Monetary advantages of Die Table Segments  Increased output 2090iwithoutwith EU 19 up to ø13Die Table Segments run time [h]/shift6,75 shifts /day22 number of stations4345 turret rotation speed [rpm]60 output/hour [pieces]154.800162.000 output/day [pieces]2.089.8002.187.000 output increase [%] 4,65% workdays/year220 profit/tablet [€]0,05 € profit/h [€]7.740 €8.100 € additinal profit/h [€] 360 € additional profit/day [€] 4.860 € additional profit/year [€] 1.069.200 €

29. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  Reduced change over time 2090iwithoutwith EU 19 up to ø13Die Table Segments number of stations4345 # of units (dies or segments)433 time to assemble oblong upper+lower punches [Min] 20 time to assemble 3 segments [Min] 5 time to assemble oblong upper+lower punches + die/station [Min] 3 1/2 time to loosen + remove [Min]3 1/225 time for change-over [Min]30150 labor costs/h [€]40 € time for change-over [h]5,020,83 frequency/month88 total costs of change-over/month [€]1.605 €267 € savings from new to old/month [€] 1.339 € savings from new to old/year [€] 16.064 € Monetary advantages of Die Table Segments Monetary advantages of Die Table Segments

30. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  Reduced cleaning time 2090iwithoutwith EU 19 up to ø13Die Table Segments number of stations4345 number of screws436 # of units (dies or segments)433 cleaning time of die table bore [Min]10 cleaning time of screw hole [Min]11 automatically cleaning of dies+screws resp. segments [Min] 4010 cleaning time [Min]12616 labor costs/h [€]40 € cleaning time [h]2,100,27 frequency/month88 total costs of cleaning/month [€]672 €85 € savings from new to old/month [€] 587 € savings from new to old/year [€] 7.040 € Monetary advantages of Die Table Segments Monetary advantages of Die Table Segments

31. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  Reduced product loss 2090iwithoutwith EU 19 up to ø13Die Table Segments number of stations4345 product loss [%] 1,50%1,00% turret rotation speed [rpm]60 output/hour [pieces]154.800162.000 output/day [pieces]2.089.8002.187.000 workdays/year220 tablet production/year 459.756.000481.140.000 product loss in # of tablets/year 6.896.3404.811.400 product loss reduction in # of tablets/year 2.084.940 profit/tablet [€]0,05 € additional profit/year [€] 104.247 € Monetary advantages of Die Table Segments Monetary advantages of Die Table Segments

32. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004  Longer life time 2090iwithoutwith EU 19 up to ø13 oblongDie Table Segments number of stations4345 # of units (dies or segments) 433 single unit price (double-sided tapered dies - oblong) [€]91,00 € single tapered segment with 15 stations (oblong) [€] 1.290,67 € set price [€]3.913,00 €3.872,01 € tablet production/year [pieces] 459.756.000481.140.000 anual compr./ station 10.692.000 life time per station 7.000.00014.000.000 sets per year 1,530,76 set cost per year [€]5.976,83 €2.957,11 € additional profit/year [€] 3.020 € Monetary advantages of Die Table Segments Monetary advantages of Die Table Segments

33. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 è increased output 1.069.200 € è reduced change over time 16.064 € è reduced cleaning time 7.040 € è reduced product loss 104.247 € è longer life time 3.020 € TOTAL BENEFIT QUANTIFICATION /YEAR1.199.571 € Monetary advantages of Die Table Segments Monetary advantages of Die Table Segments

34. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. 3 RD Arab-European Pharma Seminar 2004 Die Table Segments It‘s your decision, if you want the to be yours !