1. Janssen is proud to feature artwork created by people affected by the illnesses and diseases we are committed to treating and preventing. Key Sustainability Topics in the Pharmaceutical Industry Janssen Pharmaceutical Companies of Johnson & Johnson Janssen Global Citizenship & Sustainability Council 09.12.2013 Presented to the Int’l Society of Pharmaceutical Engineers, East Rutherford, NJ – P. Dahlin

2. Introductory Thoughts and Qualifiers Sustainability is about more than “green” Pharma industry has a significant sustainability advantage –WE HAVE A SOCIAL MISSION ! 1 ISPE Sustainability Presentation 09.12.2013 Photo: World Economic Forum – Deworming Program, Ester Havens http://forumblog.org/2012/08/best-buy-for- education-deworm-the-world/http://forumblog.org/2012/08/best-buy-for- education-deworm-the-world/

3. What are the key S topics in pharma? Depends on who you ask… Insights into key S issues from the high-level stakeholder viewpoint Highlight topics that are more actionable from the engineering community perspective 2 ISPE Sustainability Presentation 09.12.2013

4. Economic & Governance What issues are material to your business and its financial performance? 3 ISPE Sustainability Presentation 09.12.2013

5. 4 ISPE Sustainability Presentation 09.12.2013 SASB S Model Env. capital Social capital Human capital Innovation Governance

6. Economic & Governance Issues Economic viability of healthcare systems Drug safety Clinical trial oversight Ethical marketing Human rights and EHS performance in supply chain 5 ISPE Sustainability Presentation 09.12.2013

7. Social Issues Access & Affordability Public Health Issues vs. “Commercial” Diseases Employee attraction, retention, productivity & wellness 6 ISPE Sustainability Presentation 09.12.2013

8. Environmental Issues Pharma in the Environment (PIE) and Endocrine Disruption Green Chemistry Climate change & health impacts Resource efficiency Bio-based v. petroleum-based materials 7 ISPE Sustainability Presentation 09.12.2013

9. How the Engineering community impacts S Direct Resource efficiency improvements (water, energy, material savings, etc.) through smart design & retrofits (e.g., LEED) Enabling/implementing use of new processing technologies to minimize manufacturing footprint (e.g., continuous processing) Vetting of supply chain vendors to minimize ESGE risks 8 ISPE Sustainability Presentation 09.12.2013

10. How the Engineering community impacts S cont’d Indirect Controlling / reducing COGS (affordability) LEAN / Six Sigma (lean is green) Be a translator Taking personal responsibility for health & health promotion 9 ISPE Sustainability Presentation 09.12.2013

11. Thank You Janssen Global Citizenship & Sustainability Council

12. 11 ISPE Sustainability Presentation 09.12.2013 Featured Patient Artwork Accreditation: Jennifer Jacobs, Stowaway Jennifer Jacobs is a practicing New York City artist who was diagnosed with Type I diabetes at the age of twelve. She refers to her art as a “picture-essay about this exasperating, mysterious, unpredictable, motivating, fascinating, relentless nuisance.”