1. FORMATS OF NIH APPLICATIONS

2. Acknowledgment James S. Panagis, MD, MPH
Director, Orthopaedics Program
NIAMS, NIH, DHHS
6701 Democracy Boulevard, #800 Bethesda, MD (P) (F)

3. NIH 27 Institutes and Centers Budgets (FY 2005):
NIH = ~$28 Billion
NIAMS = ~$511 Million
> 70,000 applications in FY 2004

4. Types of Applications Unsolicited Solicited Program Announcement (PA)
Request for Applications (RFA)
Request for Contracts (RFC)

5. NIH Receipt, Review & Award Cycles
Cycle I
Cycle II
Cycle III
All New & Competing Applications
February 1
June 1
October 1
Revised Proposals
March 1
July 1
November 1
Scientific Review
June-July
Oct-Nov
Feb-March
Advisory Council
Sep-Oct
Jan-Feb
May-June
Earliest Start
December
April
July

6. Funding Mechanisms Training: F 31, 32, 33
Career Development: K 01, 02, 08, 22, 23, 24, 25
P 01
P 30, 50, 60
Research: R 01, 03, 15, 21, 37
R 41, 42, 43, 44
T 32
U 01

7. Career Timeline & NIH Mechanisms
Medical School
Residency
Fellowship
Junior Faculty
Career
T32
F32
K01, K08, K22, K23, R03, R21
R01, R21, K24

8. What is the Right Mechanism?
Your training & experience
What you need
What you would like to do (time & amount)

9. Career Development Award
“K” Awards

10. Mentored Research Scientist Development Award
K01

11. K01 Purpose is to develop outstanding scientists
3 – 5 yrs of supervised research experience
75 % effort
Ineligible if prior R01, R29, K(01,07,23), P(01,50)
Salary: Salary determined by I/C
NIAMS=$75,000)

12. K01
Research Dev. Support: i.e., tuition, fees & research support. Amount varies (NIAMS = $20,000)
Facilities & Admin costs: Fixed at 8%
Mentor should have independent research support (mentor is not salaried)
Standard receipt dates

13. Mentored Clinician Scientist Development Award
K08

14. K08 Purpose is to develop clinical research scientists
Similar format/regulations to K01
52.3% success rate

15. NIAMS Career Transition Award
K22

16. K22
Provides training within a NIAMS intramural lab followed by support in an extramural institution
Ineligible if prior R01, R29, SBIR/STTR, P01, P50, K08
Provides up to $150,000/YR for all years

17. K22 Intramural (Phase I): Salary based upon training &experience.
Extramural (Phase II): Salary up to $75,000. Can be supplemented. 75% effort. Up to $75,000 for research supplies.
F & A: 8%
Standard receipt dates
40.2 % success rate

18. Mentored Patient-Oriented Research Career Development Award
K23

19. K23 Purpose is to develop clinical researchers
3 – 5 yrs of support; 75% effort
Same eligibility as the other K’s
Salary : Varies by I/C. May be supplemented (NIAMS = $75,000)
Res. Development Support: Up to $25,000
F & A: 8%

20. K23 Mentors should have independent research support
Can not be salaried.
Standard receipt dates
46.6 % success rate

21. Mentored Quantitative Research Career Development Award
K25

22. K25
Purpose is to foster interdisciplinary collaboration in biomedical research by supporting career development experiences for scientists with quantitative and engineering backgrounds
3-5 YRS of support
75% effort
Similar format/regulations as other Ks

23. NIAMS Small Grant Award for New Investigators

24. R03 Funding for pilot/preliminary data
Ineligible if previous/current large mechanism support, or NIAMS R21
Receipt dates: 2/24/05, 6/24/05, 10/24/05
Up to 3 YRS of support
Up to $50,000 direct costs/YR
Limited to 2 small grant awards/career
Lower success rate due to # of apps

25. Exploratory/Developmental Research Grant

26. R21
Appropriate for early stages of research that are high risk because of possible failure, but if successful, may be of significant benefit
2 YRS of support; $275,000 split over the 2 yrs

27. R21 Program Announcements
PA : Exploratory/Developmental (R21) Bioengineering Research Grant (EBRG)
PA : NIH Exploratory/Developmental Research Grant Award (R21)

28. Shorter Duration R01
Prove feasibility, setting stage for what to follow in a competing continuation
Suggest 3 years
Avoids being “overly ambitious” in an R03, or if limited preliminary data, “high risk” for a longer duration R01

29. NIH Loan Repayment Program for Clinical Researchers
Purpose: To recruit & retain clinical investigators
Re-pays up to $35,000/YR of educational loan expenses for each YR of obligated service
Also pays 39% of loan repayment to IRS
Must agree to engage in clinical research a minimum of 2 years

30. Tips Contact NIH Program Officer (PO)
Read application instructions carefully
Focus on perfecting the abstract & specific aims
Communicate clearly & thoroughly
Allow time for a thorough editing & proofreading
Have knowledgeable colleagues review application
Send in supplemental progress materials, papers
Speak with NIH PO post-review
Be prepared to revise in response to critique

31. BE PERSISTENT

32. Resources NIAMS Homepage: http://www.niams.nih.gov
NIH Grants Page:
“Welcome Wagon”:
“Getting Started at the NIH”:
“Grant Writing Tips”:

33. Resources: Tutorials
How to Write a Grant Application:
Advice on Research Training & Career Awards:
How to Write an Application Involving Animals:
How to Write a Human Subjects Application:
Annotated R01 Grant Application: