1. Flucoral®
Pharmacological Composition Each capsule containing 150mg Fluconazole. Fluconazole is a broad spectrum Systemic Antifungal

2. Flucoral®
Mechanism of action Inhibition of cytochrome P-450→Impairment of Ergosterol synthesis in the fungal cell membrane→Interfers with fungal cell membrane function &growth→stop the fungal growth N.B: Fluconazole is highly selective inhibitor to fungal cytochrome P-450 and doesn't affect on liver cytochrome P-450

3. Flucoral®
Pharmacokinetics
The bioavailability of orally administered Fluconazole is over 90%
Absorption of fluconazole is unaffected by food or gastric acidity

4. Flucoral® Pharmacokinetics
Peak plasma concentrations (C-max) occur between 1 and 2 hours with a terminal plasma elimination half-life of approximately 30 hours after oral administration

5. Flucoral®
Pharmacokinetics Fluconazole lipophillicity will achieve tissue levels exceeding the required MICs for all pathognomonic fungi for a complete week.

6. Flucoral
Effective Against Candida Species Infection At Wide Range Of Body Sites And Tissues.

7. Flucoral

8. Flucoral

9. Flucoral® Pharmacokinetics
Fluconazole(FLUCORAL) is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug. About 11% of the dose is excreted in the urine as metabolites.

10. Excellent Eradication
Flucoral®
Excellent Eradication
Flucoral is well established as a first line management option for the treatment of localized and systemic C.albicans infections.
Micheal V. Martin;Journal of Antimicrobial Chemotherapy (1999)

11. Pityriasis Versicolor

12. Flucoral® % cure & improvement rates
Excellent eradication rates in PityriasisVersicolor
Single dose fluconazole Vs Itraconazole
% cure & improvement rates

13. Onychomycosis

14. %cure &improvement rates
Flucoral®
Excellent eradication rates in Onychomycosis
%cure &improvement rates

15. Flucoral®

16. Flucoral®

17. Flucoral®
Flucoral penetrates the nails and persists after twice weekly doses for 6 months in toenails and fingernails
Amalia del Palacio et al ,dermatophytosis treatment (2000).Madrid,Spain

18. Indications:
1: tinea Capitis.
2: Tinea cruris

19. Tinea Barbe.
Tinea Corporis.

20. Tinea Pedis.
Tinea Versicolor.

21. Onychomycosis.
Candidiasis.

22. Flucoral®
Safety
Fluconazole is contraindicated in lactating women and category C in pregnant women.

23. American Family Physician,February 15,2001;Volume 63,Number 4
Flucoral®
Monitoring of liver enzymes is not recommended during therapy with fluconazole (FLUCORAL)
American Family Physician,February 15,2001;Volume 63,Number 4

24. Journal of antimicrobial chemotherapy.1999
Flucoral®
Itraconazole is not suitable for the routine treatment of infections in patients with raised liver enzymes,history of liver diseases when treatment prolonged (>1 month) liver enzyme monitoring should be undertaken
Journal of antimicrobial chemotherapy.1999

25. Flucoral®
Flucoral is available as a box containing 2 capsules each containing Fluconazole 150mg with a price of LE.

26. Thank You