1. Pre Test !!!!!!

2. How many classes of HIV meds are currently available? 1. 1 2. 2 3. 3 4. 4 5. 5

3. A side effect with Reyataz (atazanavir) which is reversible when discontinued is? 1. Discoloration of the fingernail and toe nails 2. Hyperbilirubinemia 3. Kidney Failure 4. Liver Failure

4. HIV stands for: 1. Hawaiian Island Visitors 2. Human Immunodeficiency Virus 3. Hepatitis Injection Vaccine 4. None of the above

5. The first three steps involved in HIV cell entry include all of the following except: 1. Fusion 2. Integration 3. Attachment 4. Co-receptor binding

6. All the following are combination formulations except for? 1. Epivir 2. Combivir 3. Epzicom 4. Trizivir

7. Like Hepatitis C, HIV is… 1. A harmless virus 2. A bloodborne virus 3. A curable virus 4. None of the above

8. What HIV med causes Vivid Dreams? 1. Selzentry (Maraviroc) 2. Sustiva (Efavirenz) 3. Lexiva (Fosamprenavir) 4. None of the above

9. Living or working with a person who is infected with HIV can cause someone to get HIV 1. False 2. True

10. What must one be careful of when taking Ziagen (abacavir)? 1. Acne 2. Cough 3. Runny nose 4. Hypersensitivity reaction

11. The most common side effect found with the “D” drugs is? 1. Diarrhea 2. Nausea 3. Headaches 4. Peripheral Neuropathy

12. Consistent and correct condom use can prevent HIV 1. True 2. False

13. HIV can be transmitted by: 1. Sharing dirty needles 2. Blood 3. Semen 4. Vaginal Fluids 5. All of the above 6. None of the above

14. Before beginning Selzentry (maraviroc) what type of lab test must be performed? 1. CBC w/ Diff 2. Hct & Hgb 3. Trophile 4. LFT

15. The only HIV medication currently on the market which is injected is? 1. Retrovir 2. Fuzeon 3. Crixivan 4. Combivir

16. One of the body fluids that can transmit HIV is: 1. Tears 2. Saliva 3. Urine 4. Breast milk

17. All of the following agents are Protease Inhibitors except? 1. Prezista (darunavir) 2. Lexiva (fosamprenavir) 3. Viracept (nelfinavir) 4. Ziagen (abacavir)

18. Trizivir, although is a 3 med combo it should not be used alone because…. 1. It is too expensive 2. There are too many side effects 3. It does not sustain good results as triple nuc therapy 4. None of the above

19. The first medication used in HIV was? 1. Crixivan (Indinavir) 2. Invirase (Saquinavir) 3. Sustiva (Efavirenz) 4. Retrovir (Zidovudine)

20. What is the least number of HIV meds that can be used to treat HIV? 1. 1 2. 2 3. 3 4. 4 5. 5

21. What HIV med is used as a booster? 1. Viracept (Nelfinavir) 2. Reyataz (Atazanavir) 3. Norvir (Ritonavir) 4. Viramune (Nevirapine)

22. The newest HIV medication combined into one pill and taken once a day by two different manufacturers is? 1. Trizivir 2. Combivir 3. Atripla 4. Epzicom

23. HIV Medications 101 Fred Cruz, R.Ph. Pharmacist-In-Charge CarePlus CVS/pharmacy

24. My Personal Story

47. TEST !!!!!

48. What is Fred’s male dog’s name? 1. Thor 2. Zeuz 3. Hercules 4. Rudy

49. What is Fred’s female dogs name? 1. Xena 2. Aphrodite 3. Athena 4. None of the above

50. What is Fred’s partners occupation? 1. Pharmacist 2. Architect 3. Police officer 4. Doctor

51. How many pictures did it take to get the family picture of the dogs? 1. 50 2. 75 3. 100 4. 125

52. What made Fred interested in working with HIV? 1. HIV medications are always changing 2. His friend a pharmacist had a brother who died of HIV 3. Fred has had many friends die of HIV 4. All of the above

53. CarePlus Pharmacy Team

55. HIV Myths

56. HIV stands for: 1. Hawaiian Island Visitors 2. Human Immunodeficiency Virus 3. Hepatitis Injection Vaccine 4. None of the above

57. Living or working with a person who is infected with HIV can cause someone to get HIV 1. False 2. True

58. Like Hepatitis C, HIV is… 1. A harmless virus 2. A bloodborne virus 3. A curable virus 4. None of the above

59. Consistent and correct condom use can prevent HIV 1. True 2. False

60. HIV can be transmitted by: 1. Sharing dirty needles 2. Blood 3. Semen 4. Vaginal Fluids 5. All of the above 6. None of the above

61. One of the body fluids that can transmit HIV is: 1. Tears 2. Saliva 3. Urine 4. Breast milk

62. HIV Life Cycle

63. Videos

66. HIV: Antiretroviral Therapy HIV RNA HIV DNA HIV Nucleus Host Cell Non-Nucleoside RTI Nucleoside RTI Integrase Inhibitors Protease Inhibitors Entry Inhibitors

67. Classes of HIV Meds Protease Inhibitors (PI’s) Protease Inhibitors (PI’s) Nucleoside Reverse Transciptase Inhibitors (NRTI’s) Nucleoside Reverse Transciptase Inhibitors (NRTI’s) Non-Nucleoside Reverse Transciptase Inhibitors (NNRTI’s) Non-Nucleoside Reverse Transciptase Inhibitors (NNRTI’s) Entry Inhibitors Entry Inhibitors Integrase Inhibitors Integrase Inhibitors

68. Classes of HIV meds in the pipeline Maturation Inhibitors Maturation Inhibitors Cellular Inhibitors Cellular Inhibitors Immune Based Therapies Immune Based Therapies

69. NNRTI ’87 ’91 ’92 ’94 ’95’96 ’97 ’98 ’99 ’00 ’88 ’89’90 NRTI PI Approved Antiretrovirals Retrovir Norvir Invirase Crixivan Fortovase Kaletra Viracept Ziagen Combivir Videx Hivid Zerit Epivir Trizivir Rescriptor Sustiva Viramune ’01 Viread Emtriva Reyataz ’02’03 ’93 Agenerase FI FUZEON Retrovir, Epivir, Combivir, Ziagen, Agenerase, Lexiva and Trizivir are trademarks of GlaxoSmithKline. Videx, Zerit, Sustiva and Reyataz are trademarks of Bristol-Myers Squibb. Norvir and Kaletra are registered trademarks of Abbott. Crixivan is registered trademark of Merck. Viramune is registered trademark of Boehringer Ingelheim. Viracept and Rescriptor are registered trademarks of Agouron. Viread and Emtriva are trademarks of Gilead. Hivid, Invirase, Fortovase and FUZEON are registered trademarks of Roche Laboratories. Lexiva

70. HAART = High Active Anti-Retroviral Therapy

71. NRTI’s (Nucleoside Reverse Transciptase Inhibitors) Combivir (zidovudine + lamivudine, AZT + 3TC) Combivir (zidovudine + lamivudine, AZT + 3TC) Combivir Emtriva (emtricitabine, FTC) Emtriva (emtricitabine, FTC) Emtriva Epivir (lamivudine, 3TC) Epivir (lamivudine, 3TC) Epivir Epzicom (abacavir + lamivudine, ABC + 3TC) Epzicom (abacavir + lamivudine, ABC + 3TC) Epzicom Retrovir (zidovudine, AZT, ZDV) Retrovir (zidovudine, AZT, ZDV) Retrovir Trizivir (abacavir + zidovudine + lamivudine, ABC + AZT + 3TC) Trizivir (abacavir + zidovudine + lamivudine, ABC + AZT + 3TC) Trizivir Truvada (tenofovir DF + emtricitabine, TDF + FTC) Truvada (tenofovir DF + emtricitabine, TDF + FTC) Truvada Videx & Videx EC (didanosine, ddI) Videx & Videx EC (didanosine, ddI) Videx Viread (tenofovir disoproxil fumarate, TDF) Viread (tenofovir disoproxil fumarate, TDF) Viread Zerit (stavudine, d4T) Zerit (stavudine, d4T) Zerit Ziagen (abacavir, ABC) Ziagen (abacavir, ABC) Ziagen

72. NRTI’s in the Pipeline Racivir (RCV) Racivir (RCV) Racivir Amdoxovir (AMDX, DAPD) Amdoxovir (AMDX, DAPD) Amdoxovir Apricitabine (SPD754, AVX754) Apricitabine (SPD754, AVX754) Apricitabine Elvucitabine (ACH-126,443, Beta-L-Fd4C) Elvucitabine (ACH-126,443, Beta-L-Fd4C) Elvucitabine

73. NNRTI’s (Non-Nucleoside Reverse Transciptase Inhibitors) Intelence (etravirine, TMC-125) Intelence (etravirine, TMC-125) Intelence Rescriptor (delavirdine, DLV) Rescriptor (delavirdine, DLV) Rescriptor Sustiva (efavirenz, EFV) Sustiva (efavirenz, EFV) Sustiva Viramune (nevirapine, NVP) Viramune (nevirapine, NVP) Viramune

74. NNRTI’s in the Pipeline Rilpivirine (TMC- Rilpivirine (TMC- Rilpivirine

75. PI’s (Protease Inhibitors) Agenerase (amprenavir, APV) Agenerase (amprenavir, APV) Agenerase Agenerase Aptivus (tipranavir, TPV) Aptivus (tipranavir, TPV) Aptivus Crixivan (indinavir, IDV) Crixivan (indinavir, IDV) Crixivan Invirase (saquinavir, SQV) Invirase (saquinavir, SQV) Invirase Kaletra (lopinavir/ritonavir, LPV/r) Kaletra (lopinavir/ritonavir, LPV/r) Kaletra Lexiva (fosamprenavir, FPV) Lexiva (fosamprenavir, FPV) Lexiva Norvir (ritonavir, RTV) Norvir (ritonavir, RTV) Norvir Prezista (darunavir, DRV) Prezista (darunavir, DRV) Prezista Reyataz (atazanavir, ATV) Reyataz (atazanavir, ATV) Reyataz Viracept (nelfinavir) Viracept (nelfinavir) Viracept

76. Entry Inhibitors Fuzeon (enfuvirtide, ENF, T-20) Fuzeon (enfuvirtide, ENF, T-20) Fuzeon Fuzeon Selzentry (maraviroc, UK-427,857) Selzentry (maraviroc, UK-427,857) Selzentry Selzentry

77. Entry Inhibitors in the Pipeline Vicriviroc (SCH-417690, SCH-D) Vicriviroc (SCH-417690, SCH-D) Vicriviroc PRO 140 PRO 140 PRO 140 PRO 140 TNX-355 TNX-355 TNX-355

78. Integrase Inhibitors Isentress (raltegravir, MK-0518) Isentress (raltegravir, MK-0518) Isentress

79. Integrase Inhibitors in the Pipeline Elvitegravir (GS-9137) Elvitegravir (GS-9137) Elvitegravir

80. HIV Treatment: Then and Now ‡

81. DHS/HIV/PP ????????’s

82. Post Test HIV Meds 101

83. The first three steps involved in HIV cell entry include all of the following except: 1. Fusion 2. Integration 3. Attachment 4. Co-receptor binding

84. The first medication used in HIV was? 1. Crixivan (Indinavir) 2. Invirase (Saquinavir) 3. Sustiva (Efavirenz) 4. Retrovir (Zidovudine)

85. How many classes of HIV meds are currently available? 1. 1 2. 2 3. 3 4. 4 5. 5

86. What is the least number of HIV meds that can be used to treat HIV? 1. 1 2. 2 3. 3 4. 4 5. 5

87. What HIV med causes Vivid Dreams? 1. Selzentry (Maraviroc) 2. Sustiva (Efavirenz) 3. Lexiva (Fosamprenavir) 4. None of the above

88. What HIV med is used as a booster? 1. Viracept (Nelfinavir) 2. Reyataz (Atazanavir) 3. Norvir (Ritonavir) 4. Viramune (Nevirapine)

89. All of the following agents are Protease Inhibitors except? 1. Prezista (darunavir) 2. Lexiva (fosamprenavir) 3. Viracept (nelfinavir) 4. Ziagen (abacavir)

90. What must one be careful of when taking Ziagen (abacavir)? 1. Acne 2. Cough 3. Runny nose 4. Hypersensitivity reaction

91. The newest HIV medication combined into one pill and taken once a day by two different manufacturers is? 1. Trizivir 2. Combivir 3. Atripla 4. Epzicom

92. Trizivir, although is a 3 med combo it should not be used alone because…. 1. It is too expensive 2. There are too many side effects 3. It does not sustain good results as triple nuc therapy 4. None of the above

93. The most common side effect found with the “D” drugs is? 1. Diarrhea 2. Nausea 3. Headaches 4. Peripheral Neuropathy

94. Before beginning Selzentry (maraviroc) what type of lab test must be performed? 1. CBC w/ Diff 2. Hct & Hgb 3. Trophile 4. LFT

95. A side effect with Reyataz (atazanavir) which is reversible when discontinued is? 1. Discoloration of the fingernail and toe nails 2. Hyperbilirubinemia 3. Kidney Failure 4. Liver Failure

96. The only HIV medication currently on the market which is injected is? 1. Retrovir 2. Fuzeon 3. Crixivan 4. Combivir

97. All the following are combination formulations except for? 1. Epivir 2. Combivir 3. Epzicom 4. Trizivir

98. Helpful Basic Websites: www.aidsmeds.com www.aidsmeds.com www.aidsmeds.com www.thebody.com www.thebody.com www.thebody.com