1. Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD Thomas L. Lentz, MD No part of this image collection may be distributed outside of the Yale University Intranet.

2. Alberts, B. et al. Molecular Biology of the Cell. 4th Edition, Garland Science, New York, 2002. Gartner, L. P. and Hiatt, J. L. Color Atlas of Histology, Williams & Wilkins, Baltimore, 1994. Kerr, J. B. Atlas of Functional Histology. Mosby, London, 1999. Kessel, R. G. and Kardon, R. H. Tissues and Organs: a text-atlas of scanning electron microscopy. W. H. Freeman, San Francisco, 1979. Lentz, T. L. Cell Fine Structure. W. B. Saunders, Philadelphia, 1971. Lodish, H. et al. Molecular Cell Biology. W. H. Freeman, New York, 2000. Mizoguti, H. Color Slide Atlas of Histology. Nihon Shashin Shinbunsha, Tokyo. Young, B. and Heath, J. W. Wheater’s Functional Histology. Churchill Livingstone, Edinburgh, 2000. Micrographs taken by George Palade, Marilyn Farquhar, James D. Jamieson, Nicolai Simionescu, Maya Simionescu, David Castle, Thomas L. Lentz. Web Resources http://info.med.yale.edu/webpath/webpath.htm Cushing Library Educational Software/Cell Biology/Several Histology Resources Acknowledgements Sources of Micrographs, Diagrams and Figures

3. Lymphoid System Laboratory

8. Plasma Cell

9. Peyer’s Patches (Lymphoid Follicles) in Small Gut Germinal Center (GC)

10. Organized GALT/MALT Diffuse GALT in gut lamina propria GALT: gut-associated lymphoid tissue MALT: mucosa-associated lymphoid tissue

11. Peyer’s Patch Lymphoid follicle Germinal center

12. Lymph Node Cortex Medulla Secondary follicles Subcapsular sinus Efferent lymphatics Hilus Medullary cords Afferent lymphatic

13. Medulla Cortex Germinal centers Lymph Node

14. Subcapsular sinus Afferent lymphatic with valve (V)

15. Secondary Follicle Germinal center: B cell proliferation and maturation Mantle of resting and memory B cells

16. Reticulin stain of lymph node

17. Palatine tonsil

20. Thymus Cortex Medulla

21. Thymus Cortex (developing T cells) Medulla

22. Thymic medulla with Hassall’s corpuscles

23. Hassall’s corpuscles

24. Development of T cells in Thymus

25. Spleen

26. Red pulp White pulp PALS Trabeular artery

27. B cell mantle PALS (T cells) GC Central arteriole Spleen

28. Spleen Red Pulp Endothelial cells Venous sinus

29. Direction of blood flow in spleen

30. Organization of the spleen

31. Some Pathology

32. Benign Reactive Lymph Node

33. Which cells are responding?

34. Adenocarcinoma Metastases to Lymph Node How did the tumor cells get to this location?

35. Adenocarcinoma Metastases to Lymph Node How did the tumor cells get to this location?