1. Summary points with interesting prospects IRB – handling samples in different areas/countries Opportunities for young researchers Who reviews grants and manuscripts Incorporating newer molecular technologies to the group Large-scale, whole-genome approaches Integration of informatics, web-based, interactive approaches Role of the industry Can NoN push for more funding? Funding for infrastructure vs. funding for research NoN to promote visibility for “success stories” derived from collaborative work in the field

2. … and more… Is there a gene variant that is so highly credible that is not worth doing an effort to validate at a consortium level? Threshold for inclusion of smaller and questionable quality studies Standardization of phenotypes and exposures, how much variability allowed Quality check for genotypes Identifying coding errors based on haplotype construction Meta-analysis of microsatellite data and multiallelic data, including haplotypes: published, published-re-examined, de novo re-genotyping, prospective Pooling retrospective data, as is, with quality checks based on published information, based on re-analysis, based on (partial) re-genotyping, central QC

3. …and more… Consortia as instruments for improving the quality of primary studies Consortia as instruments for starting high quality studies also in countries where it is more difficult to do research (developing countries) Create an acceptable grading of evidence scale Selecting targets from published data, metabolic pathways, confirmed biomarkers, linkage-identified monogenetic findings, replicated whole-genome association studies Monographs and user’s guides on how to design, conduct and report genetic epidemiology studies and meta- analyses thereof (both retrospective and prospective)

4. … and more… Publication of null studies that are well designed – single studies (any visibility), negative results of consortia (high visibility) Inclusiveness in registers and definition of unit/team/investigators to be registered Filtering of eligible teams per project according to various criteria Overlap between consortia Maintaining plurality, several consortia operating in the same field Evolving nature of consortia precluding full standardization of registration information across teams

5. How about Putting slide presentations on website Split to teams working on specific themes (e.g. standardization, registries, etc) Linking all consortia websites with 1-page info to HuGENet Refer to registries of consortia in publicly available sites Create and web-link wider registries of all teams working in a field Write manuscript(s) based on what was discussed these 2 days Agree on grading levels of evidence Pilot themes for an evidence-based encyclopedia of human genome epidemiology