1. Mitochondria

2. Mitochondrial Structure (cont.)

3. Mitochondrial Structure

4. Mitochondrial Structure (cont.) MITOCHONDRIA MODELED INTERFIBRILLAR MITOCHONDRIA SUBSARCOLEMMAL MITOCHONDRIA CAPILLARY

5. 4 444

13. The Respiratory Chain I = NADH - CoQ Reductase Complex II = Succinate - CoQ Reductase Complex III = CoQ - Cytochrome C Reductase Complex IV = Cytochrome Oxidase ETS = 12 or more different electron carriers. Grouped into 4 complexes

16. Proton - Motive Force

17. Biochemical Energetics

18. Cytosolic NADH + H + Inner mitochondrial membrane 71% protein Shuttle Systems 1. Glycerol Phosphate - Fast Twitch - (Type II) Results in FADH 2 in matrix 2. Malate - Heart, liver, slow twitch Results in NADH + H + in matrix

20. Translocation of ATP, ADP, and inorganic phosphate (Pi) Cytosolic side Inner membrane Matrix side ADP 3 - ATP 4 - H 2 PO 4 - H + ADP - ATP antiport Pi - H + symport