1. IVI Overview December 10, 2014

2. VISION Developing countries free of suffering from infectious disease MISSION Discover, develop, and deliver safe, effective, and affordable vaccines for the world’s developing nations 2

3. Background International Organization – UNDP initiative – First International Organization in Korea – 35 countries and WHO as state parties Global Vaccine Research Institute – Lab facilities in Seoul – Field programs in >20 countries: Asia, Africa, Latin America 3

4. IVI Organization 4

5. Global Footprint 5

6. Bangladesh Bhutan Brazil China Ecuador Egypt India Indonesia Israel Jamaica Kazakhstan Korea Kyrgyzstan Lebanon Liberia Malta Mongolia Myanmar Nepal Netherlands Oman Pakistan Panama PNG Peru Philippines Romania Senegal Sri Lanka Sweden Tajikistan Thailand Turkey Uzbekistan Vietnam WHO Signatories to IVI’s Establishment Agreement 6 Cote D’Ivoire Kuwait Slovakia Spain Sudan UAE *States approved by the IVI BOT for accession; Instrument of Accession to be deposited with the UN Secretary General

7. Funding Major donors: As host country, Korea contributes to annual operating budget and provided IVI’s headquarters building 7

8. Major Achievements WHO prequalification of oral cholera vaccine (Shanchol™) in September 2011 8 Technology transfer driver in Asia – tech transferred new and improved vaccines against cholera and typhoid Leader in generating evidence for vaccine introduction in developing countries

9. “Bench to Patient” Approach Discovery Genotyping of pathogens Novel antigens, adjuvants New delivery mechanisms, routes of administration Development Process development Assay development Technology transfer Clinical trials Licensure, WHO PQ Introduction Demonstration campaigns Epidemiologic studies Policy & economic research Advocacy Training SUSTAINABLE VACCINE INTRODUCTION 9

10. Vaccine Portfolio and Pipeline 10 Discovery Cholera Typhoid Bivalent typhoid/ paratyphoid DevelopmentDelivery Shigella Norovirus Pneumococcal conjugate (Vi-PspA) Inactivated polio Pediatric multivalent

11. Vaccine Programs Accelerate the development and delivery of safe, effective and affordable vaccines: – Cholera: acute watery diarrhea; can be fatal if untreated – Typhoid: enteric fever; can be fatal if untreated – Dengue: “breakbone” fever; mosquito-borne 11

12. Capacity-building Vaccinology Course Symposia, workshops North Korea Program Technology transfer Korean graduate / post doc training 12

13. IVI and MOFA MOFA: IVI stakeholder and partner – Representative on IVI Board of Trustees – Support with signatory engagement KOICA – Meningitis in Niger Project – Technical advice and assistance 13

14. Thank You!