1. OBESITY AND SMOKING IN PATIENTS WITH BARRETT’S OESOPHAGUS OR OESOPHAGEAL ADENOCARCINOMA - PRELIMINARY RESLUTS FROM finbar the study Lesley Anderson BSc (Hons) Research Assistant, NICR

2. The finbar study All Ireland case-control study designed to determine possible environmental, lifestyle and genetic risk factors involved in the development of Barrett’s oesophagus and oesophageal adenocarcinoma. finbar the study

3. Information gathered Questionnaire: –gastro-oesophageal reflux symptoms – previous medical history –medication usage –Diet –Alcohol –Smoking –Weight –Psychological profile Anthropometric data - height, weight, waist-hip ratio, leg length Blood pressure 30ml blood sample - genetics, vitamin analysis, serological testing finbar the study

4. Obesity Increasing rapidly in the UK & Ireland and in the USA. 5 years prior to the interview date: –34.2% of adenocarcinoma patients –16.6% of Barrett’s oesophagus patients –19.8% of normal controls were classified as obese (>30kg/m 2 ) 193 patients with long segment BO 234 patients with oesophageal adenocarcinoma 212 normal controls Recruitment to date:

5. Body Mass Index (BMI) Odds ratios & 95% Confidence Intervals (CI) Barrett’s OesophagusOesophageal adenocarcinoma BMI (kg/m 2 ) <24.3 24.3-26.5 >26.5 1.00 (Reference) 1.06 (95% CI 0.63-1.78) 0.86 (95% CI 0.50-1.49) 1.00 1.19 (95% CI 0.66-2.16) 2.38 (95% CI 1.35-4.17) Barrett’s OesophagusOesophageal adenocarcinoma BMI (kg/m 2 ) <24.3 24.3-26.5 >26.5 1.00 (Reference) 0.75 (95% CI 0.44-1.26) 0.88 (95% CI 0.52-1.48) 1.00 1.16 (95% CI 0.65-2.07) 2.58 (95% CI 1.47-4.52)

6. Smoking Odds ratios & 95% Confidence Intervals (CI) finbar the study Barrett’s OesophagusOesophageal adenocarcinoma Smoking Never Ex-smoker Current 1.00 (Reference) 1.15 (95% CI 0.70-1.89) 1.64 (95% CI 0.88-3.03) 1.00 2.23 (95% CI 1.30-3.84) 4.97 (95% CI 2.60-9.49)

7. Sponsors of the finbar study Ulster Cancer Foundation Health Research Board (Republic of Ireland) Research & Development Office (Northern Ireland) finbar the study

8. The Finbarstudy The Finbar study finbar the study BELFAST Dr Geraldine Cuskelly Dr Ann McGinty Dr Anne Hughes Dr Damien McManus Dr Anna Gavin DUBLIN Prof Dermot Kelleher Dr Ross McManus Dr Lisa Higgins CORK Prof Gerry O’Sullivan LEEDS Prof Chris Wild Dr Laura Hardie LEICESTER Prof Janusz Jankowski ASSOCIATE INVESTIGATORS CLINICAL PANEL Mr Jim McGuigan Prof Gerry O’Sullivan Prof John Reynolds STEERING COMMITTEE Dr Liam Murray (PI) Dr Harry Comber Dr Brian Johnston Mr Jim McGuigan Prof John Reynolds Dr Peter Watson SCIENTIFIC ADVISORS Prof Chris Wild Prof Janusz Jankowski Dr Ross McManus RESEARCH TEAM BELFAST Seamus Murphy Lesley Anderson Carol Anderson Martin McAnaespie DUBLIN Majella Gallagher CORK Siobhan Reynolds