1. Monkey Restraint Device Department of Biomedical Engineering UW-Madison

2. Monkey Restraint Group Group:Kelly ToyKawai Chan Brian FrederickMiguel Benson Ross Gerber Aman Ghotra Client: B’Ann Gablet, MS Advisor: Willis Tompkins, PhD

3. Problem Statement  To modify an existing monkey restraint device in order to effectively restrain a monkey’s head for topical eye-drop administration.

4. Background Information  50 years of non-human primate studies  Rhesus are 95% genetically similar to humans  B’Ann Gabelt performs glaucoma research on rhesus monkey  Current restraint was made by Midwest Regional Primate Research Center

5. Background Material Restraint Procedure  Monkeys transported via transport cages (A)  Monkeys are pushed into treatment cage (B)  Restraint swings to vertical position

6. Background Material Restraint Process Open treatment cageClosed treatment cage

7. Product Design Specifications Client Needs  Restrain head of monkey  Compatible with existing restraint  Work with various sized monkeys  Not harm the monkey

8. Product Design Specifications Group Specs  Extremely durable  Operable by one person  Easily sanitized  Fits under protocol

9. Design #1  Durable plastic, set across bars of cage  Chin restraint  Able to slide up to chin  Locked in place by a fastener  Monkey able to cover eyes, grab

10. Design #2  Wide winged plastic sheet  Hole for monkey’s head  Keeps monkey’s hands below sheet  Locks onto bars of cage  Allows chin ducking

11. Design #3  Wide winged plastic sheet  Chin restraint that slides to monkey  Prevents monkey from using arms  Compatibility with all sized monkeys?

12. Group 2’s Designs Ross Gerber and Aman Ghotra  U-Cup with Pin  Chin Strap  Headband Strap Restraint

13. U-Cup Pin  Different pin settings  Comfortable chin post  Attach at back of cage and swivels

14. Chin Strap  Like football chin strap  Flexible durable material  Secures to back of cage

15. Headband Restraint  Fits around head and down around the chin  Straps on top act like zip ties  Monkey’s own movements tighten device

16. Group 3’s Designs Kawai and Miguel’s Designs  1. Flatboard Design  2. Stick and Clamp Design  3. Velcro Design

17. Flatboard Design View from the top

18. Stick and Clamp Design  Component: 1. Stick 1. Stick 2. Clamps 2. Clamps 3. Headrest 3. Headrest

19. Whole Device

20. Velcro Design  Components: 1. Headrest 1. Headrest 2. Two Velcro Stripes 2. Two Velcro Stripes

21. Whole Design

22. Final Decision  Velcro Design  Easy to make, components can be purchased separately