1. ISO 9001:2008 Certified U.S. Based Manufacturing Since 1928

2. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Shipping/Receiving Columbus, OH Manufacturing Complex

3. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Why Source from GFS? Manufacturer, since 1928 –ISO certified; non-cGMP Depth and diversity of core product lines Support for Research → Commercial volumes Support for custom specifications and products

4. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Equipment Capabilities and Scale (Organic Division) Kilo Lab Scale –Glassware up to 72 L scale –Distillation support up to 50L scale Short path –Bench Strip –Rotary Evaporators Long path –18” to 48” packed columns –Stainless, Hastelloy, Ceramic packing Pilot Scale –10 gal – 100 gal glass lined steel –10 gal – 200 gal Stainless –Distillation Support Rotary Evaporator 30 gal – 50 gal glass lined steel distillation pots –4’ to 12’ columns –Glass & stainless packing

5. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Equipment Capabilities and Scale (Organic Division) Plant Scale –350-500 gal Hastelloy –100-1000 gal Glass –200-1000 gal Stainless –Distillation support Short path –50 gal-500 gal glass lined Long path –4’ to 16’ column –Stainless, Hastelloy, Glass packing –Solids Handling Hastelloy and Stainless centrifugation Plant Scale Supports –Vacuum capabilities to < 10 Torr –Pressure handled to < 100 psi –Reaction conditions controlled from -40 o C to +140 o C –Distillation conditions controlled from 20 o C to 250 o C –Scrubbing supports for acid/base, ammonia and sulfide –Nitrogen used as inerting atmosphere

6. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Core Organic Technologies Reactions in Liquid Ammonia Acetylene Reactions Alkyne Chemistry Organometallic Chemistry (Mg, Li, Na) Halogen Chemistry (Cl, Br, I) Heteroaromatic Compounds

7. www.GFSChemicals.com Leaders in Small Molecule Building Blocks RC CH RC CR ' RC CCCOH RNH 2 NH 3 Liquid Ammonia

8. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Liquid Ammonia CC n Z n=2 to 7 R CCCN R NH 3

9. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Acetylene Reactions HC CR HC CC 2 OH HC CC n Cl HC CC n C CH RC CC CCOH HC CH

10. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Alkyne Chemistry RC CCHO RC CC(O)R 1 RC CCO 2 R 1 RC CCO 2 H RC CCOH RC CC 2 OH RC CH

11. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Alkyne Chemistry RC CC CR RC CC CR’ RC CC n X RC CC n C CC m X RC CH

12. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Alkyne Chemistry RC CH Benzofurans Indoles Isocoumarins Isoquinolines Pyrimidines Furopyridines

13. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Organometallics (Mg, Li, Na) R R’ Ar R (Ar) RC CR’ R(CH2) n OTHP RMgX RLi

14. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Organometallics (Mg, Li, Na) RCHO RCCOH Z E O R’ R’ CC CR RMgX RLi

15. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Halogen Chemistry (Cl, Br, I) RCC CCBr CH 3 CH 3 CCH 2 I CH 3 I Br(CH 2 )Cl Cl, Br, I

16. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Heteroaromatic Chemistry Phenanthrolines Quinolines Bipyridines Terpyridines Pyrimidines Pyridines Phenylenediamines Acetylenes

17. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Core Organic Synthetic Methods Performed at GFS Acetylene Chemistry Halogenation Dehydrohalogenation Alkylation(NH 3 ) Sonogashira Reactions Kumada Couplings Cadiot-Chodkiewicz Suzuki Coupling Trans Reductions(NH 3 ) Diels-Alder Synthesis Ethynylation Barbier Reaction Skraup Synthesis Birch Reduction Heck Reaction Grignard/Alkyl Lithium Synthesis Finklestein Reaction Phase Transfer

18. www.GFSChemicals.com Leaders in Small Molecule Building Blocks Reagents Handled Routinely at GFS in > 100 kg Quantities Acetylene Ammonia,liq. Alkyllithium Carbon disulfide Chloroformates Chlorosulfonic acid Epichlorohydrin Ethylene oxide Bromine Lithium amide Lithium metal Magnesium Sodium amide Sodium hydride Sodium metal Trialkylsilanes Iodine Hydrogen Chloride