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24. Conclusion 1. Although using simple and inexpensive building blocks is an attractive alternative to consuming more functionalized and costly reagents, chemo- and regioselectivity remain issues that limit the broad usage of these methods. 2. Practical approaches to C-H bond oxidation using reagents that are more environmentally friendly, such as oxygen, electricity, and visible light, are desirable and are being developed. 3. In terms of asymmetric catalysis, enantioselective C-C bond formation by C-H bond oxidation is still in its infancy, although ligand-accelerated transition metal catalysis and organocatalysis has enabled some growth.