1. Schizophrenia Spectrum Disorders [Instructor Name] [Class and Section Number]

2. Overview – Pt. 1 Activity: Quiz about Schizophrenia Phenomenology of Schizophrenia Activity: The Disordered Monologue The Cognitive Neuroscience of Schizophrenia

3. Activity: Quiz about Schizophrenia True or False: 1.Schizophrenia is a rare illness. 2.Schizophrenia is a brain disease. 3.Schizophrenia usually strikes older people. 4.More males than females develop schizophrenia. 5.Schizophrenia is caused by poor parenting.

4. Activity: Quiz about Schizophrenia True or False: 6.Schizophrenia is caused by street drugs. 7.People who have schizophrenia are usually violent and dangerous. 8.People with schizophrenia have multiple or split personalities. 9.Schizophrenia can be successfully treated. 10.People with schizophrenia are developmentally disabled, i.e., they have a low level of intelligence.

5. Overview – Pt. 1 Activity: Quiz about Schizophrenia Phenomenology of Schizophrenia Activity: The Disordered Monologue The Cognitive Neuroscience of Schizophrenia

6. Phenomenology of Schizophrenia John Nash, mathematicianEugen Bleuler, psychiatrist

7. Phenomenology of Schizophrenia Delusions - False beliefs that are often fixed and hard to change even when the person is presented with conflicting information.

8. Phenomenology of Schizophrenia Types of Delusions  Persecutory  Grandiose  Reference  Thought Insertion

9. Phenomenology of Schizophrenia Hallucinations - Perceptual experiences that occur even when there is no stimulus in the outside world generating the experiences

10. Phenomenology of Schizophrenia Types of Hallucinations  Auditory  Visual  Olfactory  Gustatory  Somatic

11. Phenomenology of Schizophrenia Disorganized Speech Disorganized Behavior

12. Phenomenology of Schizophrenia Negative Symptoms  Anhedonia  Amotivation  Flat Affect  Alogia

13. Overview – Pt. 1 Activity: Quiz about Schizophrenia Phenomenology of Schizophrenia Activity: The Disordered Monologue The Cognitive Neuroscience of Schizophrenia

14. Activity: The Disordered Monologue Discussion:  People with schizophrenia’s reactions to others’ perceptions of them?  Seemingly bizarre and meaningless sentences meaningless to them?  Frustrations for someone with schizophrenia trying to communicate with others? Common Disturbances  Loose associations  Neologisms  Perseveration  Clanging  Thought insertion/thought withdrawal  Delusions of being controlled

15. Overview – Pt. 1 Activity: Quiz about Schizophrenia Phenomenology of Schizophrenia Activity: The Disordered Monologue The Cognitive Neuroscience of Schizophrenia

16. Problems with cognitive function  Episodic Memory  Working Memory  Processing Speed Cognitive deficits = RISK for schizophrenia

17. The Cognitive Neuroscience of Schizophrenia  Ventral Striatum  Hippocampus  Dorsolateral Prefrontal Cortex  Anterior Prefrontal Cortex

18. Schizophrenia Spectrum Disorders Part 2: Risk Factors & Treatment

19. Overview – Pt. 2 Risk Factors for Schizophrenia Treatment of Schizophrenia

20. Risk Factors for Schizophrenia Genetic  No “schizophrenia gene”  Heterogeneous disorder  Genes associated with other mental health conditions

21. Risk Factors for Schizophrenia Environmental  Problems during pregnancy  Complications at birth  Children born to older fathers  Cannabis use  Urban settings  Minority status

22. Risk Factors for Schizophrenia Attenuated Psychotic Syndrome – Diagnosis added to DSM-V (Section III) describing individuals who show attenuated (milder) symptoms of psychosis.  Developed recently  Distress/Disability

23. Elyn Saks

24. Overview – Pt. 2 Risk Factors for Schizophrenia Treatment of Schizophrenia

25. Atypical Antipsychotics Typical Antipsychotics

26. Treatment of Schizophrenia Cognitive Enhancement Therapy (CET)  Cognitive remediation treatment  Improves cognition & social cognition  Prevents gray matter loss

27. Appendix A: Symptoms

28. Photo Attribution Slide 1 & 18 Photo Credit: Marco Castellani http://upload.wikimedia.org/wikipedia/commons/a/a6/Schizophrenia_image.jpg http://creativecommons.org/licenses/by-sa/2.0/deed.en Slide 6 Photo Credit: http://commons.wikimedia.org/wiki/File:Eugen_bleuler.jpg#mediaviewer/File:Eugen_bleuler.jpg http://en.wikipedia.org/wiki/Public_domain Slide 6 Photo Credit: Peter Badge http://commons.wikimedia.org/wiki/File:John_Forbes_Nash,_Jr._by_Peter_Badge.jpg http://creativecommons.org/licenses/by-sa/3.0 Slide 7 Photo Credit: Craig Finn http://commons.wikimedia.org/wiki/File:Artistic_view_of_how_the_world_feels_like_with_schizophrenia_- _journal.pmed.0020146.g001.jpg http://creativecommons.org/licenses/by/2.5 Slide 8 Photo Credit: Tim Shields BC https://www.flickr.com/photos/45203414@N02/4241490089/ https://creativecommons.org/licenses/by-nc/2.0/ Slide 9 Photo Credit: August Natterer http://commons.wikimedia.org/wiki/File:August_Natterer_Meine_Augen_zur_Zeit_der_Erscheinungen.jpg http://en.wikipedia.org/wiki/Public_domain Slide 10 Photo Credit: http://commons.wikimedia.org/wiki/File:Itch_02.jpg#mediaviewer/File:Itch_02.jpg http://creativecommons.org/licenses/by-sa/3.0 Slide 11 Photo Credit: http://commons.wikimedia.org/wiki/File:Cloth_embroidered_by_a_schizophrenia_sufferer.jpg http://creativecommons.org/licenses/by/2.0 Slide 11 Photo Credit: http://commons.wikimedia.org/wiki/File:Flexibilitas_cerea.JPG#mediaviewer/File:Flexibilitas_cerea.JPG http://en.wikipedia.org/wiki/Public_domain Slide 12 Photo Credit: Wes Washington http://commons.wikimedia.org/wiki/File:Portrait_of_acute_anxiety.JPG#mediaviewer/File:Portrait_of_acute_anxiety.JPG http://creativecommons.org/licenses/by-sa/3.0 Slide 17 Photo Credit: Kim J, Matthews NL, Park S http://commons.wikimedia.org/wiki/File:Schizophrenia_fMRI_working_memory.jpg http://creativecommons.org/licenses/by/2.5 Slide 20Photo Credit: https://openclipart.org/detail/58543/dna-by-kumar35885 http://creativecommons.org/publicdomain/zero/1.0/ Slide 21 Photo Credit: https://openclipart.org/detail/48349/warning-sign-by-palomaironique http://creativecommons.org/publicdomain/zero/1.0/ Slide 24 Photo Credit: http://commons.wikimedia.org/wiki/File:Thorazine_advert.jpg#mediaviewer/File:Thorazine_advert.jpg http://creativecommons.org/publicdomain/zero/1.0/ Slide 24 Photo Credit: Housed http://commons.wikimedia.org/wiki/File:Risperdal_tablets.jpg#mediaviewer/File:Risperdal_tablets.jpg http://creativecommons.org/licenses/by-sa/3.0 Slide 25 Photo Credit: http://commons.wikimedia.org/wiki/File:AFNI_screenshot.png#mediaviewer/File:AFNI_screenshot.png http://creativecommons.org/licenses/by-sa/3.0/ Slide 26 Photo Credit: http://commons.wikimedia.org/wiki/File:Insulin_shock_therapy.jpg#mediaviewer/File:Insulin_shock_therapy.jpg http://creativecommons.org/publicdomain/zero/1.0/ Slide 27 Photo Credit: John D. and Catherine T. MacArthur Foundation http://commons.wikimedia.org/wiki/File:ELYN_SAKS_9.JPG http://creativecommons.org/licenses/by/4.0/deed.en