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Tyrosine kinase signalling (review) TGF signalling Notch signalling.

Published byMakenzie Waldie Modified over 9 years ago

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Presentation on theme: "Tyrosine kinase signalling (review) TGF signalling Notch signalling."— Presentation transcript:

1 Tyrosine kinase signalling (review) TGF signalling Notch signalling

2 TGF signalling Receptor Serine/threonine kinase Activation/repression of gene expression SMAD transcription factors and regulators RanGTP, importins and exportins

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8 Flores, A. N. et al. (2014) NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer Nat. Rev. Urol. doi:10.1038/nrurol.2014.195

9 Flores, A. N. et al. (2014) NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer Nat. Rev. Urol. doi:10.1038/nrurol.2014.195

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16 Numb expression in human mammary tumors. Pece S et al. JCB 2004;167:215-221 © 2004 Rockefeller University Press

17 Loss of Numb expression in tumors is due to enhanced ubiquitination and proteasomal degradation. Pece S et al. JCB 2004;167:215-221 © 2004 Rockefeller University Press

18 Re-expression of Numb selectively suppresses growth in Numb-negative tumors. Pece S et al. JCB 2004;167:215-221 © 2004 Rockefeller University Press

19 Increased Notch signaling in Numb-negative tumors. Pece S et al. JCB 2004;167:215-221 © 2004 Rockefeller University Press

20 Effects of perturbation of Numb or Notch activity in mammary tumor primary cells. Pece S et al. JCB 2004;167:215-221 © 2004 Rockefeller University Press

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