1. Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

2. CSB Fig 02:01 Cell signalling pathways CSB Fig 02:01 Cell signalling pathways Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

3. Transducers Second Messengers II 1.JAK/STAT signaling 2.Smad signaling 3.Hedgehog signaling 4.Wnt signaling 5.Hippo signaling 6.Notch signaling 7.ER Stress signaling 8.AMP signaling

4. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:72 JAK and STAT structure CSB Fig 2:72 JAK and STAT structure

5. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:73 STAT1/DNA complex CSB Fig 2:73 STAT1/DNA complex

6. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:74 JAK/STAT heterogeneity CSB Fig 2:74 JAK/STAT heterogeneity

7. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:75 JAK/STAT function CSB Fig 2:75 JAK/STAT function

8. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:76 Smad domain structure CSB Fig 2:76 Smad domain structure

9. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:77 TGF-βR activation

10. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:78 Smad signalling CSB Fig 2:78 Smad signalling

11. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:79 Wnt signalling pathways CSB Fig 2:79 Wnt signalling pathways

12. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:80 Wnt canonical pathway CSB Fig 2:80 Wnt canonical pathway

13. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:81 Hedgehog signalling pathway

14. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:82 Hippo signalling pathway CSB Fig 2:82 Hippo signalling pathway

15. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:83 Notch signalling CSB Fig 2:83 Notch signalling

16. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:84 Notch modulation CSB Fig 2:84 Notch modulation

17. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:85 ER stress signalling CSB Fig 2:85 ER stress signalling

18. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:86 Metabolic messengers CSB Fig 2:86 Metabolic messengers

19. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:87 Metabolic signalling CSB Fig 2:87 Metabolic signalling

20. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:88 Pyruvate and Ca2+ signalling CSB Fig 2:88 Pyruvate and Ca2+ signalling

21. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:89 AMPK structure CSB Fig 2:89 AMPK structure

22. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:90 AMPK control of metabolism CSB Fig 2:90 AMPK control of metabolism

23. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CBS Fig 2:91 Omega-3 fatty acids CBS Fig 2:91 Omega-3 fatty acids