2. Today’s Agenda w Objective 13-16 notes w Practice w Objective 17- 18 notes

3. Immune System Day 6 A single event can awaken within us a stranger totally unknown to us. Saint-Exupery

5. wAwAntibody structure

6. Antibodies w 2 heavy chains (450 amino acids) w 2 light chains (220 amino acids w Connected by a (S-S) disulfide bridge. w The whole protein has 1340 amino acids.

7. Objective 14 wAwActive immunity is acquired during an infection or from a vaccination.

8. Obj.14 continued wPwPassive immunity is given when a donor’s antibodies are injected into the blood- stream or from mother.

9. Obj. 15 5 Classes of Antibodies w IgA (immunoglobulin A) w IgG (these all differ by w IgM structure and function) w IgD w IgE

10. Obj. 16 Function of Antibodies w Complement fixation w Antigen neutralization w Precipitation w Agglutination

11. Neutralization by Antibodies

12. Agglutination by Antibodies

13. Precipitation of Dissolved Antigens by Antibodies

14. Activation of Complement By Antibodies

15. Practice

16. Objective 17: Clonal Selection of T cells w T cell growth is stimulated by the protein displayed on the surface of the macrophage. w Some become active killers others become memory T cells.

17. Obj. 18: Roll of T Cells w Cytotoxic T cells attack and lyse infected cells. w Helper T cells release interleukin. w Suppressor T stop immune response

19. View Video Clip 36698 Laser Disk 11