2. Hyaluronic acid filler
Product description
mesofiller is a sterile, injectable and resorbable medical device
based on cross-linked hyaluronic acid
to be used as a temporary filler for the correction of aesthetic concerns such as wrinkles or depressions.
t allows firming the tissues and filling intradermal spaces and intercellular matrix.

3. Concentrations mesofiller soft 20 mg/ml (2%) mesofiller medium
Hyaluronic acid filler
Concentrations
mesofiller soft
20 mg/ml (2%)
mesofiller medium
25 mg/ml (2,5%)
fine lines and wrinkles in the periocular or perilabial area.
deep wrinkles, nasolabial fold, cheeks and lips.

4. Packaging contents 1 information pamphlet 1 blister
Hyaluronic acid filler
Packaging contents
1 information pamphlet
1 blister
1 * 1ml prefilled, graduated, disposable and sterile glass syringe
2 sterile 27G½ needles
2 traceability adhesive labels

5. Top quality crosslinking technique
Hyaluronic acid filler
Top quality crosslinking technique
Crosslinking agent: BDDE
The crosslinking balance is essential for maintaining both the duration and the biocompatibility of the HA filler.
There are mainly two different crosslinking agents: DVS (divinyl sulfone) and BDDE (butanediol diglycidyl ether).
BDDE is considered as a higher end product that allows an easier and more universal filling.
Crosslinking agent residues: < 50 ppb (=0.05 ppm)
Probably one of the purest HA in the market obtained thanks to an advanced purification techniques.
Standard fillers use to carry around 50 ppm residues (1’000 times more)

6. Technical data One-phase
Hyaluronic acid filler
Technical data
One-phase
Origin: biotechnogical (non-animal; produced via bacterial fermentation)
Molecular weight: MDa (raw material)
Dynamic viscosity:
mesofiller soft: 170 Pa-s
mesofiller medium: 250 Pa-s
pH:
Endotoxins: < 0.5 EU/ml (LAL test- kinetic chromogenic method)
Steam sterilised

7. Regulatory context & quality guarantees
Hyaluronic acid filler
Regulatory context & quality guarantees
MEDICAL DEVICE CE
Produced according to the ISO 9001, ISO and GMP standard (Good Manufacturing Practice).
Biocompatibility studies performed according to the ISO guide lines.