1. Semantic Medline: Multi-Document Summarization and Visualization Thomas C. Rindflesch, Ph.D. Marcelo Fiszman, M.D., Ph.D. Halil Kilicoglu, M.S. Lister Hill National Center for Biomedical Communications

2. 2 Information management application u Manipulate information in addition to documents u Manage the results of PubMed searches l Help users decide what to read u Connect knowledge from various sources u Integrate application interfaces

3. 3 Managing retrieval results Information retrieval summarization Semantic Medline breast cancer Network of relations retrieval 500 citations

4. 4 Managing retrieval results breast cancer

5. 5 Seamless integration of technologies u Information retrieval l PubMed - MEDLINE u Natural language processing: SemRep l Represent content of text with semantic predications u Abstraction summarization l Informative: Overview of most salient information u Visualization l Indicative: Links to source text and additional information

6. 6 Structured Biomedical Data UMLS Semantic Predications SemRep Informative Graph Visualize Salient Semantic Predications Summarize Semantic Medline Overview Text MEDLINE ClinicalTrials.gov PubMed Query

7. 7 Structured Biomedical Data UMLS Semantic Predications SemRep Informative Graph Visualize Salient Semantic Predications Summarize Document selection Text MEDLINE ClinicalTrials.gov PubMed Query “breast cancer”

8. 8 Structured Biomedical Data UMLS Semantic Predications SemRep Informative Graph Visualize Salient Semantic Predications Summarize MEDLINE citations MEDLINE ClinicalTrials.gov PubMed Query Text … aromatase inhibitor provides mortality benefit in early breast carcinoma… … aromatase inhibitor provides mortality benefit in early breast carcinoma … …determined the spectrum and frequency of ATM missense variants in 443 breast cancer patients… …determined the spectrum and frequency of ATM missense variants in 443 breast cancer patients …

9. 9 Structured Biomedical Data Informative Graph Visualize Salient Semantic Predications Summarize Semantic intepretation MEDLINE ClinicalTrials.gov PubMed Query UMLS Semantic Predications SemRep Text

10. 10 Semantic interpretation... …... aromatase inhibitor provides mortality benefit in early breast carcinoma … Aromatase InhibitorsBreast Carcinoma treats … … … determined the spectrum and frequency of ATM missense variants in 443 breast cancer patients … ATM geneBreast Carcinoma associated_with

11. 11 Structured Biomedical Data UMLS SemRep Informative Graph Visualize Salient Semantic Predications Summarize Semantic predications Text MEDLINE ClinicalTrials.gov PubMed Query Semantic Predications Aromatase InhibitorsBreast Carcinoma treats ATM geneBreast Carcinoma associated_with TamoxifenBreast Carcinoma treats TamoxifenPatients treats Breast CarcinomaIndividual process_of ………………

12. 12 Structured Biomedical Data UMLS SemRep Informative Graph Visualize Summarization Text MEDLINE ClinicalTrials.gov PubMed Query Salient Semantic Predications Summarize Semantic Predications

13. 13 Abstraction summarization All Predications Reduction Salient Predications u Specify a topic u Retain predications on the topic u Eliminate uninformative predications u Retain most frequent predications

14. 14 Structured Biomedical Data UMLS SemRep Informative Graph VisualizeSummarize Salient semantic predications Text MEDLINE ClinicalTrials.gov PubMed Query Semantic Predications Salient Semantic Predications Aromatase InhibitorsBreast Carcinoma treats ATM geneBreast Carcinoma associated_with TamoxifenBreast Carcinoma treats TamoxifenPatients treats Breast CarcinomaIndividual process_of ………………

15. 15 Structured Biomedical Data UMLS SemRepSummarize Visualization Text MEDLINE ClinicalTrials.gov PubMed Query Semantic Predications Informative Graph Visualize Salient Semantic Predications

16. 16 SemRepSummarize Informative graph MEDLINE ClinicalTrials.gov PubMed Query Semantic Predications Visualize Salient Semantic Predications Structured Biomedical Data UMLS Text Informative Graph treats associated_with treats Aromatase Inhibitors Tamoxifen ATM gene Breast Carcinoma

17. 17 Semantic Medline Live

18. 18 Home page

19. 19 Search MEDLINE

20. 20 Summarization options

21. 21 Summarization results

22. 22 More detail

23. 23 Substance interactions

24. 24 Acknowledgments u Caroline Ahlers u Marcelo Fiszman u Philip Goetz u Halil Kilicoglu u Anna Ripple u Graciela Rosemblat