1. Course of Immunology -introduction (2014/2015) Marta Sobotková,Tomáš Milota, Radek Špíšek, email: marta.sobotkova@fnmotol.cz@fnmotol.cz radek.spisek@lfmotol.cuni.cz tomas.milota@fnmotol.cz

2. Course structure ● Lectures -Presence in lectures is obligatory -Lectures are held every Tuesday at 8:00-9:40 - Three absences are tolerated, more frequent absences must be based on official certificate and written thesis

3. DateThemeTeacher 7.10. 2014Immune system, overview. Phagocytic cells, complement. Communication between cells of immune systems, adhesion molecules, cytokines. prof. Špíšek 14.10. 2014Antigen processing and presentation, HLA I and II class.prof. Šedivá 21.10. 2014Specific (adaptive) immunity T and B lymphocytesPharmDr.Palich - Fučíková 4.11. 2014Immunity against infectionAdkins/Bartůňkov á 11.11. 2014Immunodeficiency, vaccinationprof.Šedivá 18.11. 2014Immunity against tumors.prof. Špíšek 25.11. 2014Immunology of transplatationdr. Kalina 2.12. 2014Autoimmunity. Immunopathology.dr. Kayserová 9.12. 2014Immunopathological reactions, allergydr. Kayserová 16.12. 2014Immunotherapydr. Podrazil 6.1. 2015Clinical aspects of immune disordersprof. Bartůňková

4. ● Seminars - The first seminar is compulsory; the time of other seminars is devoted to self-studying, preparation of seminar thesis and consultations with teachers.

5. Seminar thesis ● groups of 1-2 students ● structure of thesis: -1000 – 2000 words -form of an essay -briefly & concisely & interestingly -Abstract, text and references (literature) are obligatory, subchapters are recommended ●Term of submission: until 27.10.2013 -in the digital form - has to be sent to: irena.novakova@lfmotol.cuni.czirena.novakova@lfmotol.cuni.cz

6. ● Topics of the seminar thesis Basic immunology Regulatory T cells - function and subtypes IL-17, its role in pathologic inflammatory process Immune homeostasis in the gut. Biology of NKT cells. Use of monoclonal antibodies in treatment of tumours. Modulation of the immune system by viruses. Disorders of the immune system Immunology of sepsis Role of Toll-like receptors in autoimmune disease Role of mast cells in the induction of allergic diseases Periodic fevers- genetic background Immunology of coeliac disease. Genetic defects of Toll-like receptor signaling pathways Immunotherapy IRAK-4 and MyD88 deficiency- pathophysiology and clinical presentation Specific and nonspecific immunotherapy of allergy (cellular immunotherapy, cytokines, monoclonal antibodies ) The newest strategies of cancer immunotherapy. Vitamins as regulators of the immune response

7. ● Presentation - each thesis will be presented verbally afterwards - range: 8 minutes - Powerpoint presentation (6-10 slides)

8. Citation Literature / References: 2.DRISCOLL DA, SALVIN J, SELLINGER B, et al. Prevalence of 22q11 microdeletions in DiGeorge and velocardiofacial syndromes: implications for genetic counselling and prenatal diagnosis. J Med Genet 1993: 30: 813-7. 3.SEDIVA A, BARTUNKOVA J, ZACHOVA R, et al. Early development of immunity in diGeorge syndrome. Med Sci Monit 2005: 11: 182-7. „Most of the patients are hemizygous for 22q11.2, some have defects in various loci on chromosome 10, about 10% of cases are familial (2, 3)„

9. Final appraisal ● Presence on lectures ● Seminar thesis: fulfilled / not fulfilled + verbal appraisal (after presentation) ● Verbal examination: 2 out of 50 questions

10. Evaluation of the essay: 1/ Adherence to the length limits 2/ Correct content of the essay, no serious misunderstandings 3/ Satisfactory graphical layout and style of the essay Other comments: Evaluation of the verbal presentation: 1/ Adherence to the length limits 2/ Correct content of the essay, no serious misunderstandings 3/ Satisfactory graphical layout and style of the presentation

11. Sources

12. http://imunologie.lf2.cuni.cz/ ● shedules ● presentations (download possible) ● recommended literature, links ● contacts

13. Pubmed – Entrez www.pubmed.com www.pubmed.com PUBMED BOOKS OMIM Medline Plus – http://medlineplus.gov/ http://medlineplus.gov/ TOXNET – http://toxnet.nlm.nih.gov http://toxnet.nlm.nih.gov

14. Google Scholar http://scholar.google.com/

15. Clinical sources on-line SumSearch – http://sumsearch.uthscsa.edu/ http://sumsearch.uthscsa.edu/ E-medicine – http://www.emedicine.com/ http://www.emedicine.com/ Up-to-Date – http://www.uptodate.com/ http://www.uptodate.com/ Current Controlled Trials – http://controlled-trials.com/ http://controlled-trials.com/ Orphanet – http://www.orpha.net/ http://www.orpha.net/