1. © 2006 Business Search Technologies Corporation, All rights reserved 1 Grid Search for Cancer Prevention Version 1.0 An OGSA-DAI/WebDB application system 12 May 2006 Ryuichi Yoshida Grid Technology Group, R&D Center Business Search Technologies Corporation http://www.bsearchtech.com/

2. © 2006 Business Search Technologies Corporation, All rights reserved 2 Business Search Technologies Corporation Corporate Profile:  Office –Tokyo Head office, Tsukuba branch, San-Jose branch  Established on February 9 th, 2004.  Business contents: –Commercial Search Engine Package “ WiSE ” and related services. –Software I18N (Internationalization), tool and consulting. –Grid application software development: GSCP, GridASP, etc.  URL: http://www.bsearchtech.com/

3. © 2006 Business Search Technologies Corporation, All rights reserved 3 Grid Search for Cancer Prevention Is a joint R&D project of -  CBIE (Division of Clinical and BioInformatic Engineering), Graduate School of Medicine, University of Tokyo  GTRC/AIST (Grid Technology Research Center / National Institute of Advanced Industrial Science and Technology), Japan  BST (Business Search Technologies Corporation)

4. © 2006 Business Search Technologies Corporation, All rights reserved 4 What is GSCP? An overview JSNPs OMIM PubMed PharmGKB The Web Provide an integrated query Interface over multiple databases: both public and private. (V1.0 focus on public WebDB.) Integrated query interface GSCP V1.0

5. © 2006 Business Search Technologies Corporation, All rights reserved 5 GSCP: Motivation and enablers Motivation:  Secure and integrated access to medical information, both private and public. Enabling technologies:  OGSA-DAI (Data Access & Integration) A middleware to grid-enable data resources  OGSA-WebDB Integrate web databases with OGSA-DAI environment.

6. © 2006 Business Search Technologies Corporation, All rights reserved 6 GSCP V1.0 Functional overview JSNPs OMIM PubMed PharmGKB GSCP V1.0 Provide two types of query integration for clinical WebDB users. Grid Search Multiple Search

7. © 2006 Business Search Technologies Corporation, All rights reserved 7 Multiple Search Screen level, loose integration. Distribute a single set of search conditions to multiple query screens.

8. © 2006 Business Search Technologies Corporation, All rights reserved 8 Grid Search OMIM JSNPs PharmGKB PubMed Data level, tight integration. Cross-join queries over multiple sites

9. © 2006 Business Search Technologies Corporation, All rights reserved 9 GSCP Server host OGSA-WebDB framework Grid Search Internals JSNP OMIM PubMed PharmGKB Wrappers Wrapper Proxy database JSNP OMIM PubMed PharmGKB Query UI (JSP+Servlet) Client browsers result html http request Globus Toolkit 4.0.1 OGSA-DAI SQL Query result set Grid database service OGSA-DAI interface OGSA-WebDB interface

10. © 2006 Business Search Technologies Corporation, All rights reserved 10 Project Status  V1.0 development is completed –Released 2006 March  Enhanced OGSA-WebDB enabling setting for –Maximum webdb retrieval time –Retry number –Maximum query results per webdb  Future? –More datasources ( secure access to privacy data ) –More integration: syntax level -> semantics level? ontology?

11. © 2006 Business Search Technologies Corporation, All rights reserved 11 Business Search Technologies Corporation