1. A Multilingual, Relational Database of Health Evidence Gabriel Rada, Daniel Capurro, Daniel Perez Epistemonikos foundation

2. Episte…what? EPISTEMONIKOS ( ΕΠΙΣΤΗΜΟΝΙΚΟΣ ) What is worth knowing

3. Who we are Epistemonikos is a nonprofit organization based in Santiago, Chile Our mission is “to bring high quality information closer to health decision making”

4. The problem: information overload New oral anticoagulants in atrial fibrillation

6. The problem is you dont know the secrets of PubMed ("Atrial Fibrillation"[Mesh] OR "Atrial Flutter"[Mesh] OR ((atrial OR auricular) AND (fibrillation* OR flutter*)) OR AF[Text Word]) AND ("Factor Xa/antagonists AND inhibitors"[Mesh] OR ((factor xa OR factors 10a OR fXa OR autoprothrombin c OR thrombokinase) AND inhibit[Text Word]) OR (activated AND (factor x OR factors 10) AND inhibitor*) OR xabans[Text Word] OR (antistasin OR apixaban OR betrixaban OR du 176b OR eribaxaban OR fondaparinux OR idraparinux OR otamixaban OR razaxaban OR rivaroxaban OR aygin OR ym 150 OR ym150 OR LY517717 OR darexaban OR edoxaban OR SSR126517E) OR ((dabigatran OR BIBR1048) OR ximelagatran OR AZD0837))

7. Oooops…..but you can search “systematic reviews” [best evidence]

8. Much better, ah? Yoy can start reading …see ya!

9. 8 systematic reviews for my question Wake up!!! You have to read them, compare which studies they include ….and beg they are well conducted, say the same thing and address the same studies. Out of bed, sleepyhead!!!

10. The challenge: to separate the wheat from the chaff 23,000,000 records only in PubMed 0,25% are systematic reviews

11. Our goal TO AGGREGATE ALL THE RELEVANT HEALTH EVIDENCE (FOR DECISION-MAKING) INTO A SINGLE DATABASE.

12. www.epistemonikos.org Free Released 1 year ago

13. Multilingual interface Multilingual search Translations of abstracts

14. What evidence? Systematic reviews Overviews of reviews High-quality structured summaries Primary studies included in systematic reviews

15. Systematic reviews (SR) at the centre The average SR takes about 1-year of work We rescue that effort by storing identified studies From: http://www.navigatingeffectivetreatments.org.au/understanding_systematic_reviews.html The Centre for Health Communication and Participation with support from the Australasian Cochrane Centrehttp://www.navigatingeffectivetreatments.org.au/understanding_systematic_reviews.html

16. All that effort into a single database

17. If the reviewers found it, we’ve got it Unpublished!!!

18. Where do we search?  19 databases

19. How do we feed Epistemonikos? Combination of machine technology and human collaboration

20. Automatic search and upload Selection of actual systematic reviews by a network of collaborators Extraction of the studies included in the systematic review 1 2 3

21. RECORDS (Studies, reviews, overviews) RELATIONS TRANSLATIONS Not just records ADDED VALUE ADDITIONAL DATA (metadata) VISUALIZATION

22. Relations are stored in the database

23. New anticoagulants for atrial fibrillation

24. The numbers 158,211 records 30,651 systematic reviews – The world’s biggest collection of certified systematic reviews 109,889 primary studies +200 collaborators

25. Other 16 databases RELATIONS TRANSLATIONS Not just records ADDED VALUE ADDITIONAL DATA (metadata) VISUALIZATION Cochrane Dare Pubmed Epistemonikos How Epistemonikos compares to existing resources?

26. Let’ see an example New oral anticoagulants in atrial fibrillation

29. All the evidence (systematic reviews and studies) for our question *The matrix of evidence is expected to be released at the end of this year

30. Conclusions One-stop shop for evidence Multilingual database User friendly Relation between articles answering a similar question Visualisation of ‘all the evidence’ for a specific question

31. Many thanks!! Contact us: contact@epistemonikos.org radagabriel@epistemonikos.org …or follow us in your preferred language: English: @epistemonikos Spanish: @epistemonikosEs German: @epistemonikosDe French: @epistemonikosFr ….also in Facebook and google+ Portuguese: @epistemonikosPt Italian: @epistemonikosIt Arabic: @epistemonikosAr Dutch: @epistemonikosNl Chinese: @epistemonikosZh