1. Embase Find quick, relevant answers to your biomedical questions

2. Section 1. Review / Confirm understanding of your research needs

3. Conduct systematic reviews of the literature Set up complex search strategies and alerts for stakeholders and departments Search Medline and Embase together Set up and distribute alerts relating to evidence-based medicine Access the most up to date information related to a disease that you are tracking Make sure that all relevant information is disseminated throughout the organization Monitor and track all adverse events for early and complete detection of any and all adverse effects (signaling) Make sure you respond to your internal stakeholder’s request in a timely manner Section 1. Your challenges & Research Needs

4. Section 2. Evidence Based Medicine / Systematic Searching

5. “How do you know if one treatment will work better than another, or if it will do more harm than good?” Cochrane Reviews are systematic reviews of primary research in human health care and health policy, and are internationally recognized as the highest standard in evidence-based health care.systematic reviewsevidence-based health care They investigate the effects of interventions for prevention, treatment and rehabilitation. They also assess the accuracy of a diagnostic test for a given condition in a specific patient group and setting. They are published online in The Cochrane Library.The Cochrane Library Section 2.

6. “How do you know if one treatment will work better than another, or if it will do more harm than good?” Each systematic review addresses a clearly formulated question. For example: Can antibiotics help in alleviating the symptoms of a sore throat? All the existing primary research on a topic that meets certain criteria is searched for and collated, and then assessed using stringent guidelines, to establish whether or not there is conclusive evidence about a specific treatment. The reviews are updated regularly, ensuring that treatment decisions can be based on the most up-to-date and reliable evidence. Section 2.

7. A real example of the high risks of NOT using Embase Section 2. Case Study: Embase & Evidence Based Medicine

8. Johns Hopkins’ Tragedy: Could Librarians Have Prevented a Death? Source: http://newsbreaks.infotoday.com/nbreader.asp?ArticleID=17534 Section 2. Medicine Without Evidence

9. Section 2.

11. via Advanced Limits in Advanced SearchAdvanced Search via EmtreeEmtree Section 2. EBM Terms in Embase / Emtree

12. Section 3. What is Embase and How it Supports Academic Institutions

13. Embase is the world’s most comprehensive, intelligent biomedical research tool, providing the drug and drug-related research community with reliable and authoritative content, to advance new biomedical and pharmaceutical discovery. Confidence Find all relevant articles that may not otherwise be found by alternative databases Deep Biomedical Indexing All relevant, up-to-date, biomedical information from the research literature Precise Retrieval Deep and focused research through powerful retrieval tools Section 3. What is Embase?

14. Conference proceedings Very powerful Search Environment...by including literature and information resources in a timely manner...by reading full-text to identify drugs, diseases, adverse affects, clinical trials, drug trade names etc.... by enabling advanced search filters to drill down a comprehensive search to a relevant and manageable record set Scientific Journals In Press (unpublished)...by allowing users to automate searching and result management Deep indexing using own taxonomy (EMTREE) We make sure you don’t miss any biomedical literature They only close alternative is reading all the articles Good precision and recall balance Automation and documentation Section 3. How Embase Delivers Value…

15. Section 3.1 Content

16. Emtree: Biomedical thesaurus, over 60k terms AIP and In Process: Indexing added, from 2009 Conference Abstracts: Indexing added, from 2009 1947195019742009 And counting… 2,700 records added per day 1,000,000 records added per year Section 3.1 Content Overview Embase: Fully indexed: Over 7,700 journals (including MEDLINE), 1950- MEDLINE: 2,500 journals unique to Embase, mapped to Embase indexing, 1950- (including MEDLINE Classic) Embase Classic: Digitally scanned and re-indexed, 1947-1973

17. Other topics 28% Including public health, basic biomedical science and topics included from MEDLINE Pharmacology & Taxicology 12% General Clinical Medicine 11% Genetics, Biochemistry & Molecular Biology 10% Neurology & Behavioral Medicine 8% Microbiology & Infectious Disease 7% Cardiology & Hematology 6% Psychiatry & Mental Health 6% Oncology 5% Healthcare Policy & Management 4% Allergy & Immunology 4% Pediatrics 4% Endocrinology & Metabolism 3% Obstetrics & Gynecology 3% Biomedical Engineering & Medical Devices 3% Anesthesiology & Intensive Care 3% Gastroenterology 2% Respiratory Medicine 2% Nephrology & Urology 2% Dermatology 2% Section 3.1 Embase Scope & Coverage (2012)

18. Similar overall pattern of coverage... but with two major differences 1. Pharmacology & toxicology Embase:11.2% (889 titles) MEDLINE: 8.3% (465 titles) 2. General clinical medicine Embase:10.5% (835 titles) MEDLINE: 8.9% (495 titles) Section 3.1 Embase vs MEDLINE – Scope

19. Section 3.1 Embase vs MEDLINE – Searching the Difference

20. Section 3.1 Embase Records

21. Section 3.1 Embase Records Medline on PubMed 0102030405060708091011 200 K 400 K 600 K 800 K 1.0 m

22. Embase: now covers 7960 journals (20 March 2012) Indexed by MEDLINE (e.g on PubMed) (5592 titles) Indexed at Embase (5396 titles) Section 3.1 Embase (Active) Journals in 2012 2368 journals Indexed at Embase Unique to Embase Search: [embase]/lim 3028 journals Indexed at Embase Also covered by MEDLINE Search: [embase]/lim AND [medline]/lim 2564 journals Indexed by MEDLINE Also in MEDLINE Search: [medline]/lim NOT [embase]/lim

23. Section 3.1 Journal Articles Conference Abstracts 0102030405060708091011 200 K 400 K 600 K 800 K 1.0 m

24. Section 3.2 Indexing (Emtree Thesaurus)

25. Section 3.2 Deep Indexing – EMTREE Emtree is a Life Science Thesaurus. A controlled vocabulary for Biomedicine and related Life Sciences Easy to Search Over 60,000 preferred terms and more than 270,000 synonyms Comprehensive Drug Searching Chemical names, trade names, laboratory/research codes, and more than 28,000 generic drugs and chemicals (FDA, EMEA and WHO) Up-To-Date The latest drugs, diseases, organisms and procedures are indexed and added annually Inclusive Terminology All MeSH terms, with links to more than 20,000 CAS registry number

26. 60K terms (>260,000 synonyms) and all MeSH terms 29K drug and chemical terms Emtree updated 3 times a year (back-posting each time) All drug generic names described by FDA and EMA, all International Non-Proprietary Names (INNs) described by WHO from 2000. What is mapping? Mapping means that searchers get the same results regardless of which term they use, e.g. Vioxx (synonym) or rofecoxib (the preferred term). Section 3.2 Deep Indexing – EMTREE

27. DatabaseThesaurusSearchResult EmbaseEmtree 'monoclonal antibody'/exp/dd_dt AND 'breast cancer'/exp/dm_dt AND [2009-2010]/py [Note: dt = drug therapy] 2075 PubMedMeSH "Antibodies,Monoclonal/therapeutic use“[Mesh] AND "Breast Neoplasms/drug therapy"[Mesh] Limits: Publication Date from 2009 to 2010 357 Embase vs. PubMed : in-depth indexing + Emtree tree structure Section 3.2 Deep Indexing – EMTREE

28. 2 thesaurus assisted searches but different results! Section 3.2 Embase vs PubMed

29. This article, although present in Medline, is not indexed with ‘digoxin’ and therefore our search for ‘digoxin’ and ‘antibacterial agents’ did not find this article – it’s found in Embase. Section 3.2 Embase vs PubMed

30. Language Embase on Elsevier Medline on Ovid Embase Advantage Percent Turkish61375538717% Korean1344688191% Portuguese71244227061% Dutch60644216437% Chinese53663945142136% Polish4914345713% Spanish231621371798% French39523904481% German83938566-173-2% Section 3.2 Embase vs MEDLINE – Randomized Controlled Trails

31. Product Name 2 Search TermCitations Emtree Preferred Term MeSH Preferred Term or Substance Name 3 EmbaseMedline LiptorAtrovastatinAtrovastatin 3 7,6681,654 Advair Fluticasone propionate plus Salmeterol Fluticasone propionate plus Salmeterol 3 83939 PlavixClopidogrelClopidogrel 3 9,5521,613 NexiumEsomeprazoleOmeprazole 4 1,4931,558 NorvascAmlodipine besylateAmlodipine 4 439621 EnbrelEtanerceptTNFR-Fc fusion protein 4 5,1971,375 ZyprexaOlanzapineOlanzapine 3 7,7751,498 RemicadeInfliximabInfliximab 3 8,2232,461 DiovanValsartanValsartan 3 2,725508 RisperdalRisperidone 7,9911,488 Section 3.2 Embase vs MEDLINE – Searching for Drugs