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Published byArchibald Logan Modified over 10 years ago
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WHAT YOU WILL LEARN 9.3 CELL CYCLE REGULATION
-How cancer relates to the cell cycle -The role of apoptosis -Types / Uses of stem cells
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READING Q’s NAME -When are some of the important combinations active?
-mitosis and interphase (G1, S, G2)
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DEFINE -What is cancer? -the uncontrolled growth and division of cells
READING Q’s DEFINE -What is cancer? -the uncontrolled growth and division of cells
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READING Q’s IDENTIFY -What is an example of a carcinogen that occurs in nature? -ultraviolet radiation from the SUN
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READING Q’s IDENTIFY -Which statement about apoptosis is correct?
A- Apoptosis can lead to cancer. B- Apoptosis can prevent cancer.
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READING Q’s DESCRIBE -What are stem cells?
-unspecialized cells that can develop into a variety of specialized cells Bill Nye Greatest Discoveries—CELL DIVISION
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GROUP WORK: APPLICATION NOTES
-As a group complete the application notes using your knowledge from the reading.
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Normal cell cycle is regulated by cyclin proteins
9.3 MAIN IDEA Normal cell cycle is regulated by cyclin proteins
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WHAT YOU WILL LEARN 9.3 CELL CYCLE REGULATION
-How cancer relates to the cell cycle -The role of apoptosis -Types / Uses of stem cells
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DEFINE -What is cancer? -the uncontrolled growth and division of cells
READING Q’s NORMAL CELL CYCLE DEFINE -What is cancer? -the uncontrolled growth and division of cells
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NORMAL CELL CYCLE cyclins cyclin/CDK checkpoints cyclin/CDK G1 stage
SUMMARIZE: How cells regulate the cell cycle. -Cells use _______________ and _______________ to control the cell cycle. -Different combinations of _______________ start the cell cycle at different _______________. -The cell also uses _______________ to monitor the cycle for quality control. -In _______________, the cell checks the DNA for damage. If there is any damage, the cycle won’t proceed to _______________. -In _______________, the spindle fibers are malfunctioning, the cycle won’t proceed to ___________. cyclins CDK- Cyclin dependent kinases cyclin/CDK checkpoints cyclin/CDK G1 stage S stage mitosis cytokinesis
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SEQUENCE: The cause/effects of cancer
CANCER CELL CYCLE SEQUENCE: The cause/effects of cancer uncontrolled growth/division of cells A failure in regulation of cell cycle cancer cells go unchecked crowding out normal cells--leading to tissue/organ failure
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SUMMARIZE
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ABNORMAL CELL CYCLE IDENTIFY:
Four environmental factors that cause cancer. 1-__________________________ 2-__________________________ 3-__________________________ 4-__________________________ Unregulated cancer cell growth ASBESTOS CIGARETTE SMOKE/TOBACCO X RAYS ULTRAVIOLET RADIATION
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APOPTOSIS SUMMARIZE: Information about apoptosis- APOPTOSIS IS-
-process of programmed cell death Organisms use apoptosis to- -destroy cells that are no longer needed -destroy cells damaged beyond repair Processes that use apoptosis (examples)- 1-trees losing their leaves in autumn 2-development of hands and feet in embryo
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APOPTOSIS READING Q’s IDENTIFY
-Which statement about apoptosis is correct? A- Apoptosis can lead to cancer. B- Apoptosis can prevent cancer.
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APOPTOSIS READING Q’s
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APOPTOSIS READING Q’s
1-”triggers” in body send signals for cell death [viruses/free radicals/stress/radiation] 2-capsases [proteins]: -break down cell components -produce DNases—destroys DNA in nucleus 3-cell shrinks and sends “distress” signals 4-macrophages ingest/clean away shrunken cells
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STEM CELLS LIST: Write three facts you discovered about stem cells
1-unspecialized cells that can develop into a variety of specialized cells 2- 2 types: adult & embryonic 3- can be directed to a specific type of cell Bill Nye Greatest Discoveries—CELL DIVISION
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COMPARE/CONTRAST: Adult and embryonic stem cells
-comes from various tissues in body -present from infancy thru adulthood -unspecialized cells that have potential to become specialized cells formed after fertilization -become specialized as embryo grows
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S A A S A SUMMARIZE COMPLETE: A=apoptosis S=stem cells
___ 1-After a sperm fertilizes an egg, the resulting mass of cells divides until there are about cells. ___ 2-Some cells go through a programmed death. ___ 3-Embryonic cells shrivel and die, resulting in the formation of fingers and toes. ___ 4-Unspecialized cells are either embryonic or adult. ___ 5. This event occurs in cells that are damaged beyond repair. S A A S A
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SUMMARIZE EXPLAIN: How cancerous cell growth differs from normal cell growth -The cancer cell cycle is much faster than the normal cycle. -interphase is dramatically shorter in cancer cells NORM stomach cells CANCER stomach cells Interphase 120 min 16 min Prophase 60 min 15 min Metaphase 10 min 2 min Ananphase 3 min 1 min Telophase 12 min 3 min
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CANCER DRUGS OVERVIEW: -damage DNA work in all phases of cell cycle
-interfere w/DNA & RNA growth by replacing building blocks destroy cell in S phase -interfere w/enzymes involved in DNA replication -inhibit enzymes needed to make proteins in cell cycle work during MITOSIS, can damage cells at all stages
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ILLUSTRATE
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