1. WHAT YOU WILL LEARN 9.3 CELL CYCLE REGULATION
-How cancer relates to the cell cycle
-The role of apoptosis
-Types / Uses of stem cells

2. READING Q’s NAME -When are some of the important combinations active?
-mitosis and interphase (G1, S, G2)

3. DEFINE -What is cancer? -the uncontrolled growth and division of cells
READING Q’s
DEFINE
-What is cancer?
-the uncontrolled growth and division of cells

4. READING Q’s
IDENTIFY
-What is an example of a carcinogen that occurs in nature?
-ultraviolet radiation from the SUN

5. READING Q’s IDENTIFY -Which statement about apoptosis is correct?
A- Apoptosis can lead to cancer.
B- Apoptosis can prevent cancer.

6. READING Q’s DESCRIBE -What are stem cells?
-unspecialized cells that can develop into a variety of specialized cells
Bill Nye Greatest Discoveries—CELL DIVISION

7. GROUP WORK: APPLICATION NOTES
-As a group complete the application notes using your knowledge from the reading.

8. Normal cell cycle is regulated by cyclin proteins
9.3 MAIN IDEA
Normal cell cycle is regulated by cyclin proteins

9. WHAT YOU WILL LEARN 9.3 CELL CYCLE REGULATION
-How cancer relates to the cell cycle
-The role of apoptosis
-Types / Uses of stem cells

10. DEFINE -What is cancer? -the uncontrolled growth and division of cells
READING Q’s
NORMAL CELL CYCLE
DEFINE
-What is cancer?
-the uncontrolled growth and division of cells

11. NORMAL CELL CYCLE cyclins cyclin/CDK checkpoints cyclin/CDK G1 stage
SUMMARIZE: How cells regulate the cell cycle.
-Cells use _______________ and _______________ to control the cell cycle.
-Different combinations of _______________ start the cell cycle at different _______________.
-The cell also uses _______________ to monitor the cycle for quality control.
-In _______________, the cell checks the DNA for damage. If there is any damage, the cycle won’t proceed to _______________.
-In _______________, the spindle fibers are malfunctioning, the cycle won’t proceed to ___________.
cyclins
CDK-
Cyclin dependent kinases
cyclin/CDK
checkpoints
cyclin/CDK
G1 stage
S stage
mitosis
cytokinesis

12. SEQUENCE: The cause/effects of cancer
CANCER CELL CYCLE
SEQUENCE:
The cause/effects of cancer
uncontrolled growth/division of cells
A failure in regulation of cell cycle
cancer cells go unchecked
crowding out normal cells--leading to tissue/organ failure

13. SUMMARIZE

14. ABNORMAL CELL CYCLE IDENTIFY:
Four environmental factors that cause cancer.
1-__________________________
2-__________________________
3-__________________________
4-__________________________
Unregulated cancer cell growth
ASBESTOS
CIGARETTE SMOKE/TOBACCO
X RAYS
ULTRAVIOLET RADIATION

15. APOPTOSIS SUMMARIZE: Information about apoptosis- APOPTOSIS IS-
-process of programmed cell death
Organisms use apoptosis to-
-destroy cells that are no longer needed
-destroy cells damaged beyond repair
Processes that use apoptosis (examples)-
1-trees losing their leaves in autumn
2-development of hands and feet in embryo

16. APOPTOSIS READING Q’s IDENTIFY
-Which statement about apoptosis is correct?
A- Apoptosis can lead to cancer.
B- Apoptosis can prevent cancer.

17. APOPTOSIS
READING Q’s

18. APOPTOSIS READING Q’s
1-”triggers” in body send signals for cell death
[viruses/free radicals/stress/radiation]
2-capsases [proteins]:
-break down cell components
-produce DNases—destroys DNA in nucleus
3-cell shrinks and sends “distress” signals
4-macrophages ingest/clean away shrunken cells

19. STEM CELLS LIST: Write three facts you discovered about stem cells
1-unspecialized cells that can develop into a variety of specialized cells
2- 2 types: adult & embryonic
3- can be directed to a specific type of cell
Bill Nye Greatest Discoveries—CELL DIVISION

20. COMPARE/CONTRAST: Adult and embryonic stem cells
-comes from various tissues in body
-present from
infancy thru adulthood
-unspecialized cells that have potential to become specialized
cells formed after fertilization
-become specialized as embryo grows

21. S A A S A SUMMARIZE COMPLETE: A=apoptosis S=stem cells
___ 1-After a sperm fertilizes an egg, the resulting mass of cells
divides until there are about cells.
___ 2-Some cells go through a programmed death.
___ 3-Embryonic cells shrivel and die, resulting in the formation
of fingers and toes.
___ 4-Unspecialized cells are either embryonic or adult.
___ 5. This event occurs in cells that are damaged beyond repair. S A A S A

22. SUMMARIZE
EXPLAIN:
How cancerous cell growth differs from normal cell growth
-The cancer cell cycle is much faster than the normal cycle.
-interphase is dramatically shorter in cancer cells
NORM stomach cells CANCER stomach cells
Interphase 120 min 16 min
Prophase 60 min 15 min
Metaphase 10 min 2 min
Ananphase 3 min 1 min
Telophase 12 min 3 min

23. CANCER DRUGS OVERVIEW: -damage DNA work in all phases of cell cycle
-interfere w/DNA & RNA growth by replacing building blocks
destroy cell in S phase
-interfere w/enzymes involved in DNA replication
-inhibit enzymes needed to make proteins in cell cycle
work during MITOSIS, can damage cells at all stages

24. ILLUSTRATE