1. Towards synthetic 3D dynamic cardiac Imaging Isabelle E. Magnin CREATIS-LRMN CNRS UMR 5220, Inserm U 630, Université Lyon 1, Insa-Lyon http://creatis.insa-lyon.fr

2. CREATIS - LRMN Medical Imaging Center – Lyon CREATIS - LRMN Medical Imaging Center – Lyon http://creatis.insa-lyon.fr 180 people (65 Ph D students) 180 people (65 Ph D students) Doua Campus Est Hospital ESRF, Grenoble LRMN

4. Complex Anatomy short axis Long-axis LRMN

5. -- Magnetic Resonance Imaging (MRI) 1,5 T Siemens Vision LRMN

6. Multimodal cardiac imaging MRI Anatomie Siemens, Sonata LRMN

7. Heart anatomical surfaces and volumes 3D SPECT, XRays or MRI LRMN

8. 3D multimodal cardiac images Creatis & INRIA 3D deformable finite elements LRMN

9. Deformable elastic template for 3D segmentation (Quoc Cuong Pham, PhD thesis Creatis, INPG, 2002) Initial template Nodes : 5197, Elements : 22368 9 LRMN

10. LV+RV Mapping functional data onto a surfacic model Medial surface computation LV Medial surface 10 Medial surface Endocardial surface Epicardial surface LRMN

11. PET imaging Siemens ECAT 931 LRMN

12. Multimodal cardiac imaging Metabolism FDG PET emission-image PET transmission image LRMN

13. Surface-based registration of thorax structures deformable pyramid approach [Lötjönen et al.,1999] Rigid PET-MR image registration method MRI transaxial 13 PET transmission LRMN

14. 3D functional cartographies PET (Glucosis uptake) Patient 1 Patient 2 max 0 0 LRMN

15. Recording Electro-magnetic activity Magneto-cardiography MCG data (10 patients) -BioMag laboratory (Helsinki University Central Hospital, HUCH) - 99-channel MCG device (Neuromag, Helsinki, Finland) 15 LRMN

16. Cartography of the electromagnetic activity (MCG) 2D conventional New 3D Model [Mäkela et al. 2003] LRMN

17. 3-D Functional cardiac maps Quantitative perfusion computed from 3-D FDG Positron Emission Tomography (PET) (coll. Cermep, Lyon) 17 L V Electromagnetic field computed from Magnetocardiography (coll. Helsinki LBME) LRMN

18. Physiology modeling Physiology modeling modeling organs anatomy, dynamics and physiology modeling organs anatomy, dynamics and physiology complex elastic and moving structures complex elastic and moving structures electrophysiological models electrophysiological models bio-mechanical model (FEM) bio-mechanical model (FEM) Biological, cellular models Biological, cellular models LRMN

19. A new fully-digital anthropomorphic and dynamic thorax/heart model R. Haddad, I.E. Magnin, and P. Clarysse August 2007 LRMN

20. Outline  Motivations and objectives  Difficulties  Thorax/ Heart model construction  Multimodality virtual imaging of the heart  Conclusions and Perspectives LRMN

21.  Evaluation of cardiac/thoracic image analysis algorithms Segmentation and motion tracking of cardiac/thoracic structures Multimodal Image Registration Thorax and heart image reconstruction in dynamic tomography Motivations See: Schaerer et al., Automatic segmentation in MRI sequences, EMBC 2007, SaP1B4.5 Need for a reference LRMN

22. : Synthetic Imaging Simulated realistic sequences MRI, TEP, CT, US.. In vivo imaging acquisitions A Virtual reference breathing thorax - beating heart model LRMN

23. Building the breathing thorax / Beating heart model: 1. MRI Reference image data acquisitions 2. Anatomic 3D static models (thorax & heart) 3. Models animation Breathing thorax/ Beating heart model 4. Models synchronization LRMN

24. 3. Models animation  Displacement fields fitting : Successive multi-levels non rigid FFD registrations  Deformation of the 3D model Delhay, PhD thesis 2006 LRMN

25. 2D displays of 3D estimated displacement fields (slice at medium level) mid-systoleend-diastoleearly-diastole Magnitude mm 0,00 6,00 1,50 3,00 4,50 LRMN

26. Evolution of the LV and LA volumes during the CC 22204141261082 28 16182624 LRMN

27. Dynamic combined Thorax/Heart model LRMN