1. 1 Pharmaceutical Challenges for the Semantic Web

2. 2 Elements of Successful Drug Discovery  Safety  Efficacy  Cost Effectiveness  Timeliness

3. 3 What Modern Drug Discovery Needs to Contend with Qualified Targets Lead Generation Toxicity & Safety Biomarkers Pharmacogenomics Clinical Trials Molecular Mechanisms Lead Optimization

4. 4

5. 5 New Regulatory Issues Confronting Pharmaceutics “In response to the widening gap between basic biomedical knowledge and clinical application, governments and the academic community have undertaken a range of initiatives. After decades of investment in basic biomedical research, the focus is widening to include translational research — multidisciplinary scientific efforts directed at "accelerating therapy development" (i.e., moving basic discoveries into the clinic more efficiently).” from Innovation or Stagnation, FDA Report March 2004

6. 6 Diversity of Meanings… GenesDiseases Proteins Pathways Splice Variants Genotypes Active Compounds Systems and Models Transcriptional Regulation Genetics