2. 1 5/8/2015 Tissues of the Immune Response Tissues of the Immune Response Hugh B. Fackrell Filename:tissuesv7

3. 2 5/8/2015 Structure and Function of the Lymphatic System ä Lymphatic system ä Primary Lymphoid tissues ä Secondary Lymphoid Tissues èNext

4. 3 5/8/2015 Lymphatic System: Function ä Generate lymphocytes committed to a particular antigenic specificity ä Create an environment to trap antigens from various tissues, spaces or fluids ä Provide sites where the committed lymphocytes interact with the trapped antigens èNext

5. 4 5/8/2015 Committed Lymphocytes ä Immature lymphocytes ä generated by hematopoiesis of pleuripotent stem cells within the bone marrow. ä Lymphocytes mature in the primary lymphoid organs ä Bone Marrow, Thymus, Bursa (in birds) ä Mature lymphocytes migrate to the secondary lymphoid organs ä Lymph nodes, spleen, mucosal associated lymphoid tissues

6. 5 5/8/2015 Primary Lymphoid Tissues ä B cells ä Birds ä Bursa of Fabricius ä Mammals ä Fetal Liver ä Bone Marrow ä T Cells ä Thymus

7. 6 5/8/2015 Bursa ä Location ä Structure ä Function

8. 7 5/8/2015 Avian Lymphoid System

9. 8 5/8/2015 Bursa of Fabricius:Follicles

10. 9 5/8/2015 Bursa of Fabricius: X-Section

11. 10 5/8/2015 Bursa: B cell germinal centers

12. 11 5/8/2015 B cell Origins ä Hemopoietic stem cells develop in the fetal liver ä Later they are produced in the Bone Marrow ä “Bursal equivalent” èNext

13. 12 5/8/2015 Fetal liver: Hematopoiesis

14. 13 5/8/2015 Bone Marrow Scanning EM

15. 14 5/8/2015 Bone Marrow Differentiation

16. 15 5/8/2015 Thymus ä Location ä Structure ä Circulation ä Function ä Summary Diagram

17. 16 5/8/2015 Thymus: Location

18. 17 5/8/2015 Thymus: Lobules

19. 18 5/8/2015 Thymus: X section

20. 19 5/8/2015 Thymus: Development

21. 20 5/8/2015 Thymus: Embrogenisis

22. 21 5/8/2015 Thymus: Summary Diagram

23. 22 5/8/2015 Athymic Mouse ä “Nude” mouse - lacks hair follicles ä Lacks developed thymus ä few circulating T cells ä No cell mediated immunity

24. 23 5/8/2015 “Nude Mouse”

25. 24 5/8/2015 Lymph Nodes ä Distribution ä Structure ä Circulation ä Function ä Summary Diagram

26. 25 5/8/2015 Lymphatic System

27. 26 5/8/2015 Node: Circulation

28. 27 5/8/2015 Node: TD & TI areas

29. 28 5/8/2015 Node: X section Capsule Cortex Medulla Paracortex

30. 29 5/8/2015 Node: Diagram 2

31. 30 5/8/2015 Cortex

32. 31 5/8/2015 Node: Diagram Efferent lymphatic Afferent lymphatic Primary Follicle

33. 32 5/8/2015 Node: B cells in cortex

34. 33 5/8/2015 Node: Germinal Center

35. 34 5/8/2015 Node: Reticular network

36. 35 5/8/2015 Node Follicle: Mantle of lymphocytes

37. 36 5/8/2015 Paracortex

38. 37 5/8/2015 Node T Cells Diffuse cortex

39. 38 5/8/2015 Node: T Cells in Paracortex

40. 39 5/8/2015 Node: T cell depletion

41. 40 5/8/2015 Medulla Thymic Dependent area T cells localize

42. 41 5/8/2015 Lymph Node: Medulla

43. 42 5/8/2015 Node: LM Medulla

44. 43 5/8/2015 Node: Medullary Sinus

45. 44 5/8/2015 Node: Subcapsular Sinus

46. 45 5/8/2015 Node: EM of Medulla

47. 46 5/8/2015 Node: Primary Follicle

48. 47 5/8/2015 Node: Diffuse Cortex

49. 48 5/8/2015 Node: HEV

50. 49 5/8/2015 Node: Diagram summary

51. 50 5/8/2015 Spleen ä Location ä Structure ä Circulation ä Immunological function ä Summary Diagram

52. 51 5/8/2015 Spleen: Connective Tissue

53. 52 5/8/2015 Spleen: X section low mag

54. 53 5/8/2015 Spleen : X section higher mag

55. 54 5/8/2015 Spleen: circulation

56. 55 5/8/2015 Spleen EM: Marginal zone

57. 56 5/8/2015 Marginal zone B cells

58. 57 5/8/2015 Antigen localization in Spleen

59. 58 5/8/2015 Spleen: Summary Diagram

60. 59 5/8/2015 The End