1. Hematopoiesis Simplified: Part 1 Erythropoiesis
Larry Johnson Texas A&M University

2. Hematopoiesis Simplified: Part 1 Erythropoiesis
Objectives are to:
Identify the developmental cells of
erythropoiesis
Characterize developmental changes in the cytoplasm and nucleus of these cells
Bone marrow
32583
Blood vessel

3. 19761
Bone marrow
Blood
in vessel

4. Peripheral blood 21
Erythrocytes
Reticulocytes

5. Erythropoiesis Erythrocytes No nucleus and red cytoplasm Reticulocytes
No nucleus and blue - grey cytoplasm
Orthochromatophilic
erythroblasts
Dark, small, spherical nucleus
blue – grey cytoplasm
Darkening, fractured ,spherical
nucleus and mixed pools of grey and
blue cytoplasm
Polychromatophilic
erythroblasts
Fractured, spherical nucleus and
thin rim of dark blue cytoplasm
Basophilic erythroblasts
Uniformly light, spherical
nucleus with thin rim of medium
to dark blue cytoplasm
Proerythroblasts

6. McGraw-Hill Companies

7. Erythropoiesis Proerythroblasts Erythrocytes Reticulocytes
Orthochromatophilic
erythroblasts
Basophilic
erythroblasts
Polychromatophilic
erythroblasts
Erythropoiesis

8. Orthochromatophilic
erythroblasts
Erythrocytes

9. Erythrocyte
Proerythroblast
Reticulocytes
Orthochromatophilic
erythroblast
Basophilic
erythroblast
Polychromatophilic
erythroblast
Erythropoiesis

10. Polychromatophilic
erythroblasts

11. Erythrocyte
Proerythroblast
Reticulocytes
Orthochromatophilic
erythroblast
Basophilic
erythroblast
Polychromatophilic
erythroblast
Erythropoiesis

12. Basophilic
erythroblast

13. Erythrocyte
Proerythroblast
Reticulocytes
Orthochromatophilic
erythroblast
Basophilic
erythroblast
Polychromatophilic
erythroblast
Erythropoiesis

14. Proerythroblasts

15. Erythropoiesis Orthochromatophilic erythroblasts Erythrocytes
Reticulocytes

16. Early orthochromatophilic
erythroblasts
Late polychromatophilic
erythroblasts

17. Polychromatophilic erythroblasts
Early polychromatophilic
erythroblasts

18. Basophilic erythroblasts
Proerythroblasts

19. ut 112
Orthochromatophilic
erythroblasts
RBCs
Late polychromatophilic
erythroblast
Basophilic
erythroblast
platelets
Polychromatophilic
erythroblast
Reticulocyte
Eosinophil or
basophil
Erythrocytes
Proerythroblast

20. Bone marrow
Reticulocyte
entering
blood vessel
Blood
vessel
32583

21. The End of Hematopoiesis Simplified:
Part 1 Erythropoiesis

22. Granulopoiesis is next

23. Hematopoiesis Simplified: Part 2 Granulopoiesis
Larry Johnson Texas A&M University

24. Hematopoiesis Simplified:
Part 2 Granulopoiesis
Objectives are to:
Identify the developmental cells of granulopoiesis
Characterize developmental changes in the cytoplasm and nucleus of these cells
32583
Bone marrow

25. 19761
Bone marrow
Blood
Blood

26. `
32583
Bone marrow
Developing granulocytes

27. Peripheral blood 21

28. Granulopoiesis Lobulated, dark nucleus,
mature grey cytoplasm with small granules
Neutrophils
Neutrophilic
band or stab cells
Horse-shoe shaped, darkening nucleus, grey mature cytoplasm
Neutrophilic
metamyelocytes
Oval to kidney bean-shaped, indented nucleus, grey mature cytoplasm with a weak blue tent
Large, oval, non-indented nucleus, large amount of cytoplasm with specific and non-specific granules
Neutrophilic
myelocytes
Large, oval, non-indented nucleus,
large amount of sky blue cytoplasm
with non-specific granules
Promyelocytes

30. Granulopoiesis Neutrophils Promyelocytes Neutrophilic band cells
Neutrophilic metamyelocytes

31. ut 112
Neutrophil
Neutrophilic
metamyelocytes
Neutrophilic
metamyelocyte
Platelets
Eosinophil or
basophil
Neutrophilic
myelocytes

32. Neutrophils
Promyelocytes
Neutrophilic
band cells
Neutrophilic
myelocytes
Neutrophilic metamyelocytes
Granulopoiesis

33. Neutrophilic metamyelocytes
Lymphocytes
Neutrophilic myelocytes
Unknown
nuclei
Promyelocyte
Neutrophilic
band cells
Lymphocytes
Neutrophilic
myelocytes
Neutrophilic
band cells
Neutrophilic
metamyelocytes
Neutrophilic band cell

34. Neutrophilic band cells
Neutrophils
Granulopoiesis

35. Neutrophilic
metamyelocytes
Early neutrophilic
metamyelocytes

36. Neutrophilic myelocytes

37. Late promyelocytes
Promyelocyte

38. Neutrophilic
metamyelocytes
Unknown
nuclei
Neutrophilic
myelocytes
Neutrophilic
band cells
Neutrophilic
metamyelocytes
Proerythroblast
Orthochromatophilic
erythroblasts
Orthochromatophilic
erythroblasts
Eosinophils
or basophils

39. Bone marrow White blood cell entering a blood vessel 32583 Blood

40. The End of Hematopoiesis Simplified: Part 2 Granulopoiesis