4. Dohlman CH, Harissi-Dagher, M, Graney JM. The Boston Keratoprosthesis: a new threadless design. Digital Journal of Ophthalmology. Volume 13: Number 3. 5 mm 8.5 mm 3 mm PMMA Boston Keratoprosthesis: Type 1

5. PK - penetrating keratoplasty, BCVA - best corrected visual acuity, LSCD – limbal stem cell deficiency, CHED – congenital hereditary endothelial dystrophy, RPM - retroprosthetic membrane Patient #AgeGender Previous PKComorbidity Pre-op BCVA Post-op BCVA Follow-up (months)Complications 168M0Ocular trauma, Corneal edema, GlaucomaHM20/6016RPM (YAG) 266M4Chemical burn, GlaucomaHM20/5013 367F1Aniridia, LSCD, Glaucoma, NystagmusHM20/30016 452M3CHED, GlaucomaCF20/10015 545M0Aniridia, Glaucoma, Nystagmus20/30020/10015 656M3Congenital glaucomaCF 11 772M3Chemical burn, GlaucomaHMCF8RPM (no Tx) 868M3Aniridia, LSCD, Glaucoma, NystagmusHM20/20011 949F3Immune stromal keratitis, Glaucoma20/10020/3008 1078M5Infectious ulcer, Glaucoma, High myopiaLP20/2008 1153M0Topical anesthetic keratitis, Multiple infectious ulcersHM20/507 1262M0Stevens Johnson SyndromeCF20/3015 1365M1Aniridia, LSCD, nystagmus20/40020/15014RPM x2 (YAG) 1435F1Aniridia, LSCD,Glaucoma NystagmusCF20/20014 Inflammation, RPM (YAG) 1569M2HSV keratitis, GlaucomaCF20/15011Inflammation 1638M1 Traumatic corneal scar, Fibrous and epithelial ingrowthLPHM9 Inflammation, RPM x3 (YAG) 1779M1Chronic uveitis, GlaucomaHMCF4RPM (YAG) 1884F0Aphakic bullous keratopathyCF20/604 1950F0Aniridia, LSCD, Glaucoma, NystagmusCF20/2004

6. PK - penetrating keratoplasty, BCVA - best corrected visual acuity, LSCD – limbal stem cell deficiency, CHED – congenital hereditary endothelial dystrophy, RPM - retroprosthetic membrane, PCO – posterior capsular opacification. Patient #AgeGender Previous PKComorbidity Pre-op BCVA Post-op BCVA Follow-up (months)Complications 2057M3Chemical burn, Angle closure glaucomaLPCF16 2156M0Pseudomonas ulcer, Angle closure glaucomaHM20/6014 2228M0 HSV keratitis HM20/6012 Inflammation, RPM (YAG and surgical membranectomy) 2350M1Aniridia, LSCD, NystagmusCF20/3007 2450M0Aniridia, LSCD, Glaucoma, Nystagmus20/150 11 2556F5CHEDHM20/3009 52F0Aniridia, LSCD, Glaucoma, NystagmusCF20/1008 Inflammation, RPM (YAG) 2759M3HSV keratitisLP20/608 2866F1Congenital cataract, PBK, GlaucomaCF20/608 2984F0PBKHM20/3007Inflammation 3079F1PBK, Glaucoma, UveitisCF20/3006 3162M0LSCD, GlaucomaHM20/807 3263M1Aniridia, LSCD, NystagmusHM20/20015RPM 3357M2Traumatic corneal scar, aphakia and aniridia20/30020/406 3486M2Lattice dystrophy, GlaucomaCF20/3009 Inflammation, PCO (YAG) 3594F1PBK, GlaucomaHMCF4 3650M2Traumatic corneal scar, HSV keratitis, GlaucomaLP20/2003 3744M0 Aniridia, LSCD, Salzmann nodules, High myopia, GlaucomaLP20/804

7. BCVA presented as median (range). All others presented as total number or mean +/- standard deviation. Fresh corneal graftFrozen corneal graft Demographics # patients (total)19 (5F, 14M)18 (6F, 12M) Autoimmune10 Chemical21 Other1617 Glaucoma1615 Age (years)61 +/- 1461 +/- 16 Duration of follow up (months)10.5 +/- 48.5 +/- 4 Best corrected visual acuity Pre-op BCVACF (20/100 - LP)HM (20/150 - LP) Post-op BCVA (3 months)20/200 (20/30 - HM)20/150 (20/40 – CF) Retention100% Complications Leaks, tissue necrosis or melt00 inflammation (sterile uveitis/vitritis)34 Retro-prosthetic membrane63 Infectious endophthalmitis00

8. Frozen Cornea Group Fresh Cornea Group

12. Thank you!