1. "Geroscience“ The New Science of Aging The Buck Institute for Age Research

2. Where we are and what’s next Interdisciplinary research “Geroscience” It’s our time

4. What next?

5. 2020 2030 2040 2050 2080

6. Lifestyle/nutrition choices to maximize healthspan Individualized medicine Therapeutic interventions in AD, PD, cardiovascular disease, cancer etc.

8. Interdisciplinary Research

9. The Microbiologist, the Biochemist and the Pharmacologist ….

10. Sir Alexander Fleming

11. 1929

13. Penicillin was unstable, especially at low and high pH. Penicillin was produced in small quantities by even the most prolific cultures. Penicillium grows well only in surface culture.

14. "I forgot about that some years ago.“ Fleming at the1939 International Microbiological Congress

15. Nine long years…..

16. Florey and Chain Penicillin's therapeutic action and its chemical composition. How to isolate and concentrate penicillin (Oxford, London, USA) Published in 1940. 1943 before effective methods developed.

18. What if …?

19. Our own “Fleming” moment

20. Lifespan extension with a drug Science (2000) 289:1567-9

22. U54 Mechanism To establish Centers for Interdisciplinary Research in the Biomedical Sciences “interdisciplinary research takes bits and pieces from the contributing disciplines and integrates them in ways that produce a new conceptual framework” Solve complex problems that are refractory to traditional approaches

23. Geroscience Commonality of aging and disease mechanisms Failures in single discipline approaches in aging The need for new approaches to the organization of aging research?

24. The Aging – Disease divide Research Groups University departments Institutes National Institutes of Health –NIA Foundations

25. The aging/disease connection Lifespan extension postpones disease Aging mechanisms are disease mechanisms

26. Examples?

27. McColl and Lithgow, unpublished

28. What is Geroscience? A new scientific field Cutting edge discoveries about the tight relationship between disease and aging Interdisciplinary The science that will combat aging disease and extend life expectancy

29. What is Geroscience? Biology, biochemistry, microbiology, cell biology, evolutionary biology, biomechanics, biotechnology, bioenergetics, structural biology, Physical chemistry, medicinal chemistry, organic chemistry Control analysis, mathematical modeling, bioinformatics, biostatistics pharmacology, toxicology, medchem, Medicine.

30. Mus musculus S. cerevisiae C. elegans Protein Aggregation young vs. old disease vs. control Protein Preparation SDS insoluble pellet 1% SDS treatment, centrifugation, washing of SDS pellet 70% formic acid treatment (solublization) SDS ‘insoluble’ fraction for MS analysis The ‘Insolubleome’ Project: Multiple Systems ID gels iTRAQ quantitative MS & MS/MS proteomics

31. What is geroscience?

32. Geroscience is just the foundation

33. Critical excellence New equipment New buildings New programs and new science

34. If not now, when?

35. It’s our turn at bat

36. If not here, where?

41. Why us?

42. We are better, more innovative and creative Flat structure Single site, no departments Speak with one voice; geroscience

44. What is Geroscience? A new scientific field Cutting edge discoveries about the tight relationship between disease and aging Interdisciplinary The science that will combat aging disease and extend life expectancy

45. ER stress response, cell death and neurodegeneration

46. Parkinson’s disease A role for Iron and oxidative stress? lipoic acid, Q 10 Julie Andersen

47. Tumor Suppression and Aging Tumor Suppressor mechanisms Aging Phenotypes Care- takers prevent/repair DNA damage, mutations Gate- keepers eliminate/ arrest damaged/ mutant cells Apoptosis Cell Senescence Longevity assurance “Organismal Lifespan” Science 2006, 312. pp. 1381 -1385