1. Cerebrovascular Accident Aka: Stroke Brain Attack

2. http://www.strokecenter.org/ education/index.html

3. In this Session Brain structure and function Cerebral circulation Haemorrhagic stroke TIA Ischaemic stroke Manifestations Diagnosis and management Long term disabilities

4. Review of Brain Structure & Function

5. Cerebral Cortex –Divided into Hemispheres –Functions Motor - Controlling voluntary movements Sensory - Registers and processing sensations Association - Higher mental functions Language - Comprehension and Production

7. Cerebral Hemispheres: Lobes –Frontal –Temporal –Parietal –Occipital

10. Other Brain Structures –Brainstem –Medulla –Reticular formation

12. Other Brain Structures –Thalamus

14. Other Brain Structures –Cerebellum

16. Other Brain Structures –Hypothalamus

18. Language Wernicke’s Area –Temporal lobe –Recognition of spoken & written language –Composition of spoken and written language

19. Language Broca’s Area –Frontal lobe –Speech motor function

21. Coordination of Language in the Brain - How do we read aloud?

22. Vision

24. Cerebral Circulation

27. Arteries supplying the Brain Aortic Arch  Common Carotid Artery (left & right)  internal carotid artery (Left & Right)  Circle of Willis Aortic Arch  Subclavian Arteries  Vertebral Arteries (Left & Right)  Merge to form Basilar Artery  Circle of Willis Circle of Willis  left & right: Anterior, Middle & Posterior Cerebral Arteries

29. Definition of Stroke Acute focal neurological deficit as a result of vascular disorder

30. Epidemiology Third leading cause of death Over 70% strokes in people aged > 65 yr Ave. age males 68 yr, female 74 yr 1998 Age-standardised stroke mortality (per 100,000 pop) is 43 male, 42 female A leading cause of Disability

31. Risk Factors for Stroke Advanced age Systolic hypertension Diabetes mellitus Hypercholesterolemia Carotid artery stenosis TIAs CIGARETTE SMOKING Lack of exercise CV disease especially atrial fibrillation Increased weight

32. Non-Modifiable Risk Factors Age –Risk doubles for each decade after 55 years of age Gender –Men slightly higher than women Race Heredity

33. AGE and STROKE

34. Modifiable Risk Factors HypertensionRR 4.0 DiabetesRR 1.8 SmokingRR 1.7 Coronary diseaseRR 2.2 TIARR 3.9 Atrial fibrillationRR 2.6-4.5 HyperlipidemiaRR 1.8-2.6

35. Modifiable Risk Factors For ischaemic stroke: Being overweight increases risk by 22% Being obese increases risk by 64%

36. Diet and Stroke Fish: 3 servings a day associated with a 6% lower risk of stroke Fruits and vegetables: >5 servings a day associated with a 26% lower risk of stroke Meat: Each daily serving associated with a 24% increased risk of stroke Reduced-fat milk: associated with a lower risk of stroke vs full-fat milk Chocolate: High consumption associated with a 29% lower risk of stroke

37. Diet and Stroke Coffee: 3 to 4 cups per day associated with a 17% lower risk of stroke Tea: ≥3 cups per day associated with a 21% lower risk of stroke Sugar-sweetened beverages: high intake associated with increased obesity, diabetes, metabolic syndrome, and coronary heart disease Whole grains: high intake associated with a 21% lower incidence of cardiovascular events Rice: intake not associated with risk of stroke

38. Types of Stroke Haemorrhagic AND Ischaemic

39. Haemorrhagic Stroke 15% of strokes Release of blood into the extravascular space Caused by: –Hypertension –Aneurysms –Head Injury

40. Berry Aneurysm Cause unknown Usually around Circle of Willis

42. Haemorrhagic Stroke Rupture of blood vessel causes: –Haemorrhage –Oedema –Compression Death is common

43. Haemorrhage Intracerebral haemorrhage Subarachnoid haemorrhage

44. Transient Ischaemic Attack (TIA) Ministroke or Brain angina Fleeting attack of paralysis, numbness, tingling, aphasia, unilateral blindness or dizziness Zone of penumbra without central infarction Last less than 24 hours

45. TIA’s Warning First month after a TIA, carries a 4-8% risk of stroke First year, 12-13%; 24-29% over 5 years Note: Do not have associated pain (rare), so people may ignore them Person should seek immediate medical attention

46. Ischaemic Penumbra Prolonged hypoperfusion (<10 ml/100 gm/min) leads to Cell death Ischaemic penumbra is a zone of dysfunctional but not dead brain tissue surrounding an infarct Dysfunctional tissue may infarct “Brain is Time”- need treatment within 3 hours

47. Ischaemic Stroke 85% of all strokes Ischaemic: lack of blood flow Caused by –Emboli –Thrombosis Types are Thrombotic Stroke, Cardiogenic Embolic Stroke, Lacunar Stroke

48. Thrombotic Stroke Most common Common sites are the origins of internal carotid, vertebral arteries and junctions of basilar and vertebral arteries Normally a single cerebral artery is affected

50. Cardiogenic Emboli Stroke Caused by a moving blood clot Most common site is middle cerebral artery Most emboli originate in the left heart Atrial fibrillation and other heart disease predisposes to embolus formation

51. Lacunar Stroke Small infarcts in deeper, noncortical parts of brain or brain stem Cause can be embolism, hypertension, small haemorrhages Leave lacunae upon healing Produce “lacunar syndromes” MRI for diagnosis

52. Manifestations

53. Terminology Hemiplegia – Paralysis on one side of body Hemiparesis – weakness on one side of body Hemianopia –vision loss in one side of visual field Aphasia –language disturbance (speech, comprehension, writing) Dysarthria – slurred speech

54. Terminology Diplopia – double vision Dysphagia – difficulty swallowing Agnosia – impairment of recognition of sensory stimuli Ataxia – imbalance Apraxia – inability to properly execute movements

55. Presentations of Acute Stroke Alteration in Consciousness Stupor, delirium, coma, confusion, memory loss, seizures Headache; severe and/or neck or facial pain (Not common) Aphasia Facial weakness or asymmetry

56. Presentations of Acute Stroke Weakness, paralysis, or sensory loss Ataxia (poor balance, clumsiness, or difficulty walking) Visual loss, monocular or binocular Intensive vertigo, double vision

57. Anterior Cerebral Artery Occlusion Paralysis of contralateral leg Paresis of contralateral arm Problems making decisions Speech disturbance (aphasia if left hemisphere stroke) Some sensory loss over toes, foot, leg

58. Middle Cerebral Artery Occlusion Contralateral hemiplegia (face & arm) Contralateral Sensory impairment Speech disturbance (aphasia), including difficulty in comprehending written words and writing Some visual field loss

59. Posterior Cerebral Artery Occlusion Visual distubances (Hemianopsia, colour blindness) Memory deficits Loss of all sensory modalities (thalamus)

60. Basilar Artery Occlusion Complete obstruction of the basilar artery is usually rapidly fatal Rapid onset of unconsciousness and deepening coma. Supplies the Brain Stem

61. Vertebral Artery Occlusion Vertigo at onset Visual distubances (diplopia) Ataxia Dysphagia Dysphonia

62. Stroke Diagnosis Neurological Assessment Neuroimaging –Eg. CT, MRI (important for differentiating ischaemic from haemorrhagic stroke) Vascular Imaging –Eg. Angiography Carotid Ultrasound

63. Management: Ischaemic Stroke Goal: protection of penumbra zone –Maximize cerebral blood flow and blood volume, reduce viscosity –Maintain perfusion pressure Recanalization with thrombolytic therapy Eg. Tissue plasminogen activator (tPA), streptokinase, urokinase Anticoagulants to block occlusive processes (eg. Aspirin)

64. Long Term Disabilities Motor deficits Language and speech problems Dysarthria Aphasia Denial or hemiattention