1. Caffeine Nikola Zemánek

2. SOURCES Caffeine = natural substance (63 types of plants ) COFFE BEANS TEA LEAVESCOCOA – COCOA NUTS SOURCES Caffeine = natural substance (63 types of plants ) MOST COMMONLY :

3. HISTORY FRIEDRICH FERDINAND RUNGE HISTORY 15th century – pharmacological effect 16th century – coffeehauses in Mecca 17th century – first coffeehauses in Europe 1820 – first isolation (from coffee) Tea in China – tousands years ago

4. CHEMISTRY VIEW CHEMICAL NAME : 3,7–dihydro–1,3,7–trimethyl–1H-purine-2,6-dione Alkaloid of the methylxanthyne family Pure state – crystalline white powder ALTERNATE NAMES : 1,3,7-trimethylxanthine, coffeine, thein, guaranine, methyltheobromine, mateine

5. Biochemistry view – How does the caffeine work ? chemical changes in the brain : 1) blocking adenosine receptors 2) dopamine effect 1) BLOCKING ADENOSINE RECEPTORS STIMULATION NERVE CELLS RELEASE THE HORMONE ADRENALINE + GLUCOSE 2) INCREASING LEVEL OF DOPAMINE POSITIVE EFFECT : IMPROVEMENT THE MOOD + AGILITY NEGATIVE EFFECT : INCREASED HEART RATE AND RESPIRATION...

6. ANOTHER VIEW - ARTISTIC

7. USE STIMULATING EFFECT SOFT DRINKS CocaCola, coffee, energy drinks caffeine PILLS (students – night without sleep, possibility of overdose !!! ) caffeine benzoate – for treating headache

8. CONTENT OF CAFFEINE

9. Molecule of caffeine is very popular....

10. SOURCES OF INFORMATIONS http://chemistry.about.com/ http://en.wikipedia.org/ http://www.answers.com/

11. THANK YOU