1. RABIES VIRUS

2. What’s this?

3. Morphology and structure
Replication
Pathogenesis
Clinical symptoms
Diagnosis
Prevention and Treatment

4. Morphology
bullet-shaped;
nm in diameter; nm long.

5. structure Capsid N-protein Core -ssRNA Envelope
L-protein (large protein)
---RNA dependent RNA polymerase RNP
Capsid N-protein
---protect RNA from hydrolysis
P-protein
Envelope
Bilipid layer
M-protein (matrix protein)
G-protein (glucoprotein)
---spike
---bind to the receptor of the host cell

9. Rabies is an RNA virus. The genome encodes 5 proteins designated as N, P, M, G, and L. The order and relative size of the genes in the genome are shown in the figure below. The arrangement of these proteins and the RNA genome determine the structure of the rabies virus.

10. Replication Adsorption Penetration Uncoating Biosynthesis
Assembly and release

12. biosynthesis
-ssRNA
RNA polymerase
+ssRNA
-ssRNA protein
virus

13. Pathogenesis CNS afferent fibers efferent fibers
nerve endings salivary gland
Neuromuscular organs and tissues
junction
muscles
Virus

14. Clinical symptoms Early stage (1-3days) fever(37.5-38) vomit
wound:pain,red,itching
Exciting stage(1-3days)
fever(39-40)
hydrophobia:pharyngeal muscle cramp,dyspnea
dehydration
Paralytic stage(15-20hs)
nerve fiber paralysis
respiratory and circulatory failure
death

15. Diagnosis Isolating the dog(7-10days) Pathogenic history
cerebral smear or slice
immunofluorescent stain

19. Prevention and treatment
Kill wild dogs
Keep away from dogs
Clean the wound
Passive immunity
vaccine

21. Contributers Bian Shu Cong Ping Mu Xueru Shao Cong Zhang Jingjing
Zhu Wenying
Cheng Wei
Hu Chen
Li Yuntao
Li Daowei
Wang Shengxi

22. thank you!