1. PowerPoint Lecture Outlines to accompany
Hole’s Human
Anatomy and Physiology
Eleventh Edition
Shier w Butler w Lewis
Chapter 9
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

2. Chapter 9 Muscular System
Three Types of Muscle Tissues
Skeletal Muscle
usually attached to bones
under conscious control
striated
Cardiac Muscle
wall of heart
not under conscious control
striated
Smooth Muscle
walls of most viscera, blood vessels, skin
not under conscious control
not striated

3. Structure of a Skeletal Muscle
organ of the muscular system
- skeletal muscle tissue
- nervous tissue
- blood
- connective tissues
fascia
tendons
aponeuroses

4. Connective Tissue Coverings
epimysium
perimysium
fascicles
endomysium
muscle
fascicles
muscle fibers
myofibrils
thick and thin filaments

5. Skeletal Muscle Fibers
sarcolemma
sacroplasm
sarcoplasmic reticulum
transverse tubule
triad
cisternae of sarcoplasmic reticulum
myofibril
actin filaments
myosin filaments
sarcomere

6. Sarcomere
I bands
A bands
H zone
Z lines
M line

7. Myofilaments Thin Filaments Thick Filaments composed of actin
associated with troponin and tropomyosin
Thick Filaments
composed of myosin
cross-bridges

8. Neuromuscular Junction
also known as myoneural junction
site where an axon and muscle fiber meet
motor neuron
motor end plate
synapse
synaptic cleft
synaptic vesicles
neurotransmitters

9. Motor Unit single motor neuron
all muscle fibers controlled by motor neuron

10. Stimulus for Contraction
acetylcholine (ACh)
nerve impulse causes release of ACh from synaptic vesicles
ACh binds to ACh receptors on motor end plate
generates a muscle impulse
muscle impulse eventually reaches sarcoplasmic reticulum
and the cisternae

11. Excitation Contraction Coupling
muscle impulses cause sarcoplasmic reticulum to release calcium ions into cytosol
calcium binds to troponin to change its shape
position of tropomyosin is altered
binding sites on actin are exposed
actin and myosin molecules bind

12. Sliding Filament Model of Muscle Contraction
When sarcromeres shorten, thick and thin filaments slide past one another
H zones and I bands narrow
Z lines move closer together

13. Cross-bridge Cycling
myosin cross-bridge attaches to actin binding site
myosin cross-bridge pulls thin filament
ADP and phosphate released from myosin
new ATP binds to myosin
linkage between actin and myosin cross-bridge break
ATP splits
myosin cross-bridge goes back to original position

14. Relaxation acetylcholinesterase – rapidly decomposes Ach
remaining in the synapse
muscle impulse stops
stimulus to sarcolemma and muscle fiber membrane
ceases
calcium moves back into sarcoplasmic reticulum
myosin and actin binding prevented
muscle fiber relaxes

15. Major Events of Muscle Contraction and Relaxation

16. Energy Sources for Contraction
1) Creatine phosphate 2) Cellular respiration
creatine phosphate – stores energy that quickly converts ADP to ATP

17. Oxygen Supply and Cellular Respiration
Anaerobic Phase
glycolysis
occurs in cytoplasm
produces little ATP
Aerobic Phase
citric acid cycle
electron transport chain
occurs in the mitochondria
produces most ATP
myoglobin stores extra oxygen

18. Oxygen Debt
Oxygen debt – amount of oxygen needed by liver cells to use the accumulated lactic acid to produce glucose
oxygen not available
glycolysis continues
pyruvic acid converted to lactic acid
liver converts lactic acid to glucose

19. Muscle Fatigue inability to contract commonly caused from
decreased blood flow
ion imbalances across the sarcolemma
accumulation of lactic acid
cramp – sustained, involuntary muscle contraction

20. Heat Production by-product of cellular respiration
muscle cells are major source of body heat
blood transports heat throughout body

21. Muscular Responses Threshold Stimulus
minimal strength required to cause contraction
Recording a Muscle Contraction
twitch
latent period
period of contraction
period of relaxation
refractory period
all-or-none response

22. Length-Tension Relationship

23. Summation process by which individual twitches combine
produces sustained contractions
can lead to tetanic contractions

24. Recruitment of Motor Units
recruitment - increase in the number of motor units activated
whole muscle composed of many motor units
more precise movements are produced with fewer
muscle fibers within a motor unit
as intensity of stimulation increases, recruitment of motor units continues until all motor units are activated

25. Sustained Contractions
smaller motor units (smaller diameter axons)
- recruited first
larger motor units (larger diameter axons)
- recruited later
produce smooth movements
muscle tone – continuous state of partial contraction

26. Types of Contractions isotonic – muscle contracts and changes length
concentric – shortening contraction
isometric – muscle contracts but does not change length
eccentric – lengthening contraction

27. Fast and Slow Twitch Muscle Fibers
Slow-twitch fibers (type I)
always oxidative
resistant to fatigue
red fibers
most myoglobin
good blood supply
Fast-twitch fatigue-resistant fibers (type IIb)
intermediate fibers
oxidative
intermediate amount of myoglobin
pink to red in color
resistant to fatigue
Fast-twitch glycolytic fibers (type IIa)
white fibers (less myoglobin)
poorer blood supply
susceptible to fatigue

28. Smooth Muscle Fibers Compared to skeletal muscle fibers shorter
single, centrally located nucleus
elongated with tapering ends
myofilaments randomly organized
lack striations
lack transverse tubules
sarcoplasmic reticula not well developed

29. Types of Smooth Muscle Visceral Smooth Muscle Multiunit Smooth Muscle
single-unit smooth muscle
sheets of muscle fibers
fibers held together by gap junctions
exhibit rhythmicity
exhibit peristalsis
walls of most hollow organs
Multiunit Smooth Muscle
less organized
function as separate units
fibers function separately
irises of eye
walls of blood vessels

30. Smooth Muscle Contraction
Resembles skeletal muscle contraction
interaction between actin and myosin
both use calcium and ATP
both are triggered by membrane impulses
Different from skeletal muscle contraction
smooth muscle lacks troponin
smooth muscle uses calmodulin
two neurotransmitters affect smooth muscle
acetlycholine and norepinephrine
hormones affect smooth muscle
stretching can trigger smooth muscle contraction
smooth muscle slower to contract and relax
smooth muscle more resistant to fatigue
smooth muscle can change length without changing
tautness

31. Cardiac Muscle located only in the heart
muscle fibers joined together by intercalated discs
fibers branch
network of fibers contracts as a unit
self-exciting and rhythmic
longer refractory period than skeletal muscle

32. Characteristics of Muscle Tissue

33. Skeletal Muscle Actions
origin – immovable end
insertion – movable end
prime mover (agonist) – primarily responsible for movement
synergists – assist prime mover
antagonist – resist prime mover’s action and cause movement in the opposite direction

34. Body Movement Four Basic Components of Lever rigid bar – bones
fulcrum – point on which bar moves; joint
object - moved against resistance; weight
force – supplies energy for movement; muscles

35. Levers and Movement

36. Major Skeletal Muscles

37. Major Skeletal Muscles

38. Muscles of Facial Expression

39. Muscles of Mastication

40. Muscles of Facial Expression and Mastication

41. Muscles That Move the Head and Vertebral Column

42. Muscles That Move the Head and Vertebral Column

43. Muscles That Move the Pectoral Girdle

44. Muscles That Move the Pectoral Girdle

45. Muscles That Move the Arm

46. Muscles That Move the Arm

47. Muscles That Move the Arm

48. Muscles That Move the Forearm

49. Muscles That Move the Forearm

50. Muscles That Move the Forearm

51. Cross Section of the Forearm

52. Muscles That Move the Hand

53. Muscles That Move the Hand

54. Muscles of the Abdominal Wall

55. Muscles of the Abdominal Wall

56. Muscles of the Pelvic Outlet

57. Muscles of Pelvic Outlet

58. Muscles That Move the Thigh

59. Muscles That Move the Thigh

60. Muscles That Move the Thigh

61. Muscles That Move the Leg

62. Muscles That Move the Leg

63. Muscles That Move the Leg

64. Muscles That Move the Leg

65. Muscles That Move the Foot

66. Muscles That Move the Foot

67. Muscles That Move the Foot

68. Life-Span Changes myoglobin, ATP, and creatine phosphate decline
by age 80, half of muscle mass has atrophied
adipose cells and connective tissues replace muscle tissue
exercise helps to maintain muscle mass and function

69. Clinical Application Myasthenia Gravis autoimmune disorder
receptors for ACh on muscle cells are attacked
weak and easily fatigued muscles result
difficulty swallowing and chewing
ventilator needed if respiratory muscles are affected
treatments include
drugs that boost ACh
removing thymus gland
immunosuppressant drugs
antibodies