1. How was DNA determined to be the genetic material? A connection between data and conclusions! A picture is worth 1000 words!!!

2. Your Assignment: Identify the purpose of the given experiment. State your scientists’ hypothesis. Explain the methods (include new vocab!). Explain the data they got. Connect the experiment to the conclusion about DNA

3. Griffith and Avery

5. Hershey and Chase

7. Photo 51 and Chargaff’s Rules (Watson and Crick’s Model)

9. Messelson and Stahl

11. DNA Replication and Enzymes Using a video, review the process of DNA replication Identify the role of the following enzymes: –Helicase, DNA polymerase (more than one role), nuclease, single-stranded binding protein, ligase, primase –Classify enzymes as: leading strand replication, lagging strand replication, proofreading (may have more than one function –Clarify the direction the template strand is read and the place on the new strand where a nucleotide is added. Identify the role of the additional phosphate groups on the nucleotide.

12. Summary of Replication

13. Beyond the double helix: DNA’s organization

14. Histones Material: Protein Function: Organize DNA Big Idea #2 (Regulation):Wh at does acetylation do?

15. DNA Methylation Adding a CH3 to the DNA backbone can shut off the “gene” from working. Gene: sequence of DNA that codes for a particular protein

16. Big Idea #2 & 3: The function of DNA can be controlled at the DNA structural level! This is “epigenetics”! Our epigenetics friends will delve further into this :)

17. Chromosome vs. Chromatin Almost a continuum When does DNA condense into chromosomes? Why does the cell expend energy to organize the DNA into chromosomes?