1. Synthetic route Start with: To make: USING A GRIGNARD REACTION!

2. Clickers: which sequence would be a workable route to the required Grignard reagent? A: B: C:

3. Clickers: which sequence would be a workable route to the required Grignard reagent? A: B: C:

4. Clickers: Which is the best electrophile to use?

5. Clickers: Which is the best electrophile to use?

6. Clickers: What reagent(s) would be best for the last step? A:KOtBu, tBuOH B:H 2, Pd, MeOH C:H 2 SO 4 (aq.) D:Zn(Hg), HCl

7. Clickers: What reagent(s) would be best for the last step? A:KOtBu, tBuOH B:H 2, Pd, MeOH C:H 2 SO 4 (aq.) D:Zn(Hg), HCl