1. Genetics

2. Gregor Mendel

3. Genetic Concepts Phenotype –Physical characteristics of organism –Result of gene expression –Biochemical properties of proteins determine physical characteristics of organism Genotype –Set of alleles present in genome of organism –Alleles are versions of genes

4. Segregating Traits in Sweet Pea

5. Genetic Crosses Monohybrid –cross between two variants of a single trait –ABO type A x ABO type B Dihybrid –cross between two variants of two traits –ABO type A, Rh+ x ABO type B, Rh-

6. Mendel’s Monohybrid Crosses GY Pea Color Trait x All Yellow P Generation F1F1 x F2F2 ¼ of progeny green

7. What Does It Mean, Mendel??? The disappearance of the green trait in F 1 means it is recessive The appearance of only the yellow trait in F 1 means it is dominant A recessive trait is seen if only recessive alleles of that gene are present The dominant trait is seen if 1 or 2 alleles of that gene are present THERE MUST BE TWO ALLELES OF EACH GENE THE ALLELES SEPARATE DURING REPRODUCTION

8. Mendel’s Dyhybrid Crosses Y Pea Color Trait & Height Trait x All Yellow & Tall P Generation F1F1 G x

9. Mendel’s Dihybrid Cross 9/16 yellow & tall 3/16 green & tall 3/16 yellow & short 1/16 green & short F2F2

10. What Does It Mean, Mendel??? Yellow and Tall are dominant traits; green & short are recessive EITHER ALLELE CONTROLLING COLOR CAN ASSORT WITH EITHER ALLELE CONTROLLING HEIGHT

11. Mendel’s Principles Law of Segregation –There are two alleles (distinct copies) of each gene in the genome of an organism –The two alleles are separated during meiosis and put into separate gametes Law of Independent Assortment –Any allele of one gene may assort with any allele of any other gene –All possible allelic combinations are possible if enough gametes are produced

12. Chromosomes & Genes Homologous Chromosomes Sister Chromatids Non-Sister Chromatids Loci Alleles Maternal Homolog Paternal Homolog

13. Meiosis I

14. Crossing Over (Not with John Edward) Y Z y z

15. Meiosis II

16. Inheritance Patterns Complete Dominance Co-dominance Intermediate Dominance

17. Complete Dominance/Recessiveness Phenotype: ABO type A Genotype: I A I A, I A O Phenotype: ABO type B Genotype: I B I B, I B O Phenotype: ABO type O Genotype: OO

18. Co-Dominance Phenotype: ABO type A Genotype: I A I B Both A & B alleles encode functional enzymes Both enzymes work at same time Both modifications are made simultaneously Phenotype is combined effect of both A & B enzymes

19. Intermediate Dominance A dosage effect B better than B’ BB > BB’ > B’B’ Red, pink, white flowers RR > RW > WW

20. Linkage Genes on same chromosome are separated by crossing over during meiosis I Genes located near each other, on the same chromosome, are separated infrequently Often they are inherited together This is termed “being linked”

21. Chromosomal Sex Determination In most organisms, males & females have a unique pair of chromosomes which determine sex XY mechanism –Males – XY; females - XX ZW mechanism –Males – ZZ; females - ZW X0 mechanism –Males – X_ ; females - XX

22. Sex Linkage Genes on the X or Y chromosomes are sex-linked A phenotype caused by a gene on the X chromosome will appear in males more frequently Normal

23. DNA

24. Complementary Base Pairing