1. By: A.Abdeyazdan With best regards to: Dr.M.Mokhtari Embryo Implantation

2. What is Embryo Implantation ?

3. Preimplantation Embryo - Hatching use of lytic factors Uterus ( implantation window) -Thickness of endometrial wall - growth of secretory glands 7 days after ovulation - produce of decidual cell 9 to 10 days after ovulation - produce of pinopodes for endocytose - secret of progesterone

4. Pinopodes In human are almost on non- villi Surface of endometrium. Have mitochondria and glycogen. Produce because of progesterone secreting. They have villi on their surface that is Perfect to close the trophoblast to endometrium. Integrin on pinopodes and muc1 on endometr will help to implantation

5. Decidualization Edema Place for natural killer Source of nutrients for embryo Control the growth of embryo Immune actions Control the maternal vesseln system Secret some factors for develop of placenta Growth factors are important for decidalization 10% of gene expression in decidualization is in control of embryo( like EPCR)

6. Effecter factors in Implantation Hormones (estrogen, progesterone, prostaglandin) Growth factors Cytokines LIF

7. Implantation

8. Blastocyst attach to endometrium with L-selectin & CCR2, CCR5

9. Invasion

10. Breaching of trophoblast

11. Early placental development Cyncytiotrophoblast Syncytiotrophobalst in Endometrium

12. Power by: M.Zendehboudi By: A.Abdeyazdan With best regards to: Dr.M.Mokhtari Embryo Implantation