1. Cell injury p.2 and cell death SYLLABUS: Robbins and Cotran, Pathologic Basis of Disease, Chapter: Cellular Responses to Stress and Toxic Insults: Adaptation, Injury, and Death excluding: hypertrophy hyperplasia metaplasia

2. Cell injury p.2 and cell death 28Kidney amyloidosis 39Caseous necrosis (tuberculosis, lymph node) 40Liquefactive necrosis (peptic ulcer) 43Balser necrosis (enzymatic fat necrosis) s/35Epidermal cyst 30Leukokeratosis (oral mucosa sample)

3. -amyloid deposits in glomeruli and in the walls of blood vessels (metachromatic stain) Kidney amyloidosis

6. -area of necrosis: - amorphous, granular, pink debris with no visible nuclei or cell contours -elements of TB granuloma: -giant Langhans cells -epithelioid cells -lymphocytes -lymph node structure Caseous necrosis (tuberculosis, lymph node)

10. -defect (excavation) caused by the necrosis of the previously pathologically altered tissue -thin layer of necrotic tissue debris -underlying inflammatory infiltration Liquefactive necrosis (peptic ulcer)

13. Balser necrosis (enzymatic fat necrosis) -shadowy outlines of necrotic fat cells -basophilic deposits replacing fat in cells -surrounding inflammatory infiltration

14. Balser necrosis (enzymatic fat necrosis)

16. Epidermal cyst -normotypical (sometimes flattened) squamous epithelium lining the cyst -keratin masses filling the cyst

17. Epidermal cyst

19. Leukokeratosis (oral mucosa sample) -keratinizing squamous epithelium (with granular and keratinized layer) (no skin appendages visible) (.ppt demonstration only, no slides during the microscopy lab)

20. Leukokeratosis (oral mucosa sample)