2.  It is a primary, superficial, infective ulcer having a dendritic shape caused by Herpes Simplex Virus (epitheliotropic type).

3. Dendritic ulcer stained with fluorescin

4. Herpes Simplex virus

5. Primarily responsible, above waist Orofacial & ocular infection HSV-1 Transmitted sexually Genital diseases, passed to neonates HSV-2

7. Virus becomes dormant in trigeminal (V) ganglion Inter-neuronal spread 1ry HSV-1 infection; in childhood Direct contact of skin or mucous membrane with virus-laden lesions or secretions

8. Fever Menstruation Drugs Psychic stress Low resistance

9. Recurrence occurs with decreased body resistance Virus becomes active Vesicles in mouth, genitalia, cornea

10.  Close-up view of early herpes outbreak shows small, grouped blisters (vesicles) and lots of inflammation (erythema).

11.  HSV infection is ubiquitous, with an estimated one third of the population worldwide suffering from recurrent infections.

13.  Patients with HSV keratitis may complain of the following: › Pain › Photophobia › Poor vision › Profuse lacrimation › Blepharospasm

15.  Corneal stromal inflammation  Infectious epithelial keratitis

16.  Endothelitis  Blepharo- conjunctivitis

18.  Dendritic ulcer stained with fluorescin

19.  Dendritic ulcer stained with Rose Bengal

20. Eye infectionThroat infectionEczema herpeticum

21. Erythema multiformNervous systemWidespread infection

23. Bacterial & fungal keratitis Peripheral ulcerative keratitis Superficial punctate keratitis

24. Acanthamoeba keratitis Photokeratitis Interstitial keratitis

25. Local Antiviral (acyclovir) Atropine Local antibiotic Bandage General Vit A & Vit C Acyclovir tablet Resistant Debridement Cauterization Therapeutic keratopathy