1. Forces that Drive Evolution Mutation, Natural Selection, Genetic Drift and Gene Flow

2. Forces that Drive Evolution Objectives: Understand that evolution is change over time Understand that there are four main forces that “drive” evolution: – Mutation – Natural selection – Genetic drift – Gene flow Be able to explain each, and how they work

3. Evolution – A Definition (or three) Variation of inherited traits within a population over time as a consequence of mutation, genetic recombination, or gene flow Descent with modification Change over time

4. Charles Darwin – The Theory of Evolution English naturalist (1809-1882) Traveled the world (including the Galapagos Islands) on the Beagle, making observations, collecting samples, formulating the Theory of Evolution Published On The Origin of Species over 20 years after his voyage on the Beagle. It was meant to explain the diversity of life, not the origin.

5. Why is Darwin so important? Provided evidence for descent with modification (i.e., change over time, i.e., evolution) Proposed a natural mechanism for how species evolve (i.e., natural selection)

6. Evolution helps explain… The diversity of life on Earth How new species are formed Why organisms look and behave the way they do How organisms respond to changes in their environment Why some groups of organisms are more diverse than others

7. Darwin’s Evidence for Evolution Animal distributions - Closely related organisms found in geographical proximity

8. Darwin’s Evidence for Evolution Fossils - Sequential emergence of different groups and transitional forms

9. Homology - The spatial and developmental equivalence of traits that may look quite different Darwin’s Evidence for Evolution

10. Vestigial features - Speaks to imperfect “design”. Best explained by the persistence of shared traits. Darwin’s Evidence for Evolution

11. Yeah, but what actually causes evolution, anyway?!?

12. Mutation – Random changes in DNA sequence Natural selection Genetic Drift – Change in gene pool due to chance Gene Flow – Change in allele frequency due to migration Forces That Drive Evolution

13. U.S. Department of Energy Human Genome Program, http://www.ornl.gov/hgmis Mutations Affect Genes, Proteins, Traits

14. Natural Selection From “Understanding Evolution”

15. What is “Natural Selection”? Individuals in a population that are better adapted (variation) to survive in an environment (competition) pass on their traits to more offspring in the next generation (differential reproductive success, heritability) H.E. Hoekstra

16. Natural Selection: Pocket Mouse Video H.E. Hoekstra

17. Natural Selection Activities Survival of the Skittles http://salsa.nescent.org/activity-2-survival-of-the- skittles/)http://salsa.nescent.org/activity-2-survival-of-the- skittles/ “Clip Birds” (http://www.ucmp.berkeley.edu/education/lessons/clipbirds/)http://www.ucmp.berkeley.edu/education/lessons/clipbirds/ Teddy Graham Evolution Several online simulations… – EvoDots (http://faculty.washington.edu/herronjc/SoftwareFolder/EvoDots.html)http://faculty.washington.edu/herronjc/SoftwareFolder/EvoDots.html – AIPOTU (http://aipotu.umb.edu/)http://aipotu.umb.edu/ – PhET NS Simulator (http://phet.colorado.edu/en/simulation/natural-selection)http://phet.colorado.edu/en/simulation/natural-selection – McGraw-Hill Natural Selection Simulator http://www.mhhe.com/biosci/genbio/virtual_labs/BL_12/BL_12.html http://www.mhhe.com/biosci/genbio/virtual_labs/BL_12/BL_12.html ENSI Evolution Lessons (http://www.indiana.edu/~ensiweb/evol.fs.html)http://www.indiana.edu/~ensiweb/evol.fs.html

18. Genetic Drift – Change in gene pool due to chance Genetic Drift From “Understanding Evolution”

19. Genetic Drift – Change in gene pool due to chance Genetic Drift The “jar of marbles” example From “Understanding Evolution”

20. Genetic Drift – Change in gene pool due to chance Genetic Drift The “jar of marbles” example From “Understanding Evolution”

21. A population’s size is reduced for at least one generation Genetic Drift - Bottlenecks From “Understanding Evolution”

22. Genetic Drift – Founder Effect Establishment of a new population (colony) by just a few individuals

23. Question: Why are genetic drift, bottlenecks and founder effects important in evolution? Answer: They result in reduced genetic variation. And why does this matter???

24. Because reduced genetic variation can mean decreased ability to adapt to new selective pressures, such as… Climate changeEvolving pathogens or…

25. Change in allele frequency due to migration Gene Flow From “Understanding Evolution”

26. Questions?