1. Saeideh Dahaghin MD, PhD

2. Osteoarthritis  A chronic disease of joints  No cure available  pain is the main symptom of osteoarthritis  The most common reason of disability  To increase the quality of life in osteoarthritis pain-killers are the first choice  Surgery is the next available treatment  Generalised OA, pain-killers

3. Data on medication use in POHEM-OA British Colombia Linked Health Data base (2003-2004) probability of medication use in OA patient which was varied base on duration of OA and level of pain Four type of pain-killers was used by OA patients; Acetaminophen NSAIDs Coxibs Opioid POHEM-OA represent the side effects of pain-killers in five categories : Gastro intestinal, Cardio vascular disease, Stroke, dyspepsia, other generic side effects

12. The effect of pain-killers on HUI is different in older age Older people after 60 years old suffers more often from side effects We would like to study the balance of side effect and benefit on HUI in people older than 60 years old.

13. To study the effect of side effect in various age group we did not have pohem-OA ready Change the parameter of the probability of getting side effect of medication for various age group HUI and HALE for various age group Behnam version of POHEM.