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Copyright © 2009 Pearson Education, Inc. Extensions of Mendelian Genetics Chapter 4 Lecture Concepts of Genetics Tenth Edition
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Copyright © 2009 Pearson Education, Inc. 4.1Alleles Alter Phenotypes in Different Ways Wild type Loss of function Null Gain of function New alleles are produced by mutation
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Copyright © 2009 Pearson Education, Inc. 4.2Geneticists Use a Variety of Symbols for Alleles
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Copyright © 2009 Pearson Education, Inc. 4.3Neither Allele Is Dominant In Incomplete, or Partial, Dominance
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Copyright © 2009 Pearson Education, Inc. Figure 4.1
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Copyright © 2009 Pearson Education, Inc. 4.4In Codominance, the Influence of Both Alleles in a Heterozygote Is Clearly Evident (There’s no “blending” of phenotypes)
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Copyright © 2009 Pearson Education, Inc. 4.5Multiple Alleles of a Gene May Exist in a Population 4.5.1The ABO Blood Groups 4.5.2The A and B Antigens
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Copyright © 2009 Pearson Education, Inc.
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Figure 4.2
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Copyright © 2009 Pearson Education, Inc. 4.5Multiple Alleles of a Gene May Exist in a Population 4.5.3The Bombay Phenotype
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Copyright © 2009 Pearson Education, Inc. Figure 4.3
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Copyright © 2009 Pearson Education, Inc. 4.5Multiple Alleles of a Gene May Exist in a Population 4.5.4The white Locus in Drosophila More than 100 alleles
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Copyright © 2009 Pearson Education, Inc. 4.1
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Copyright © 2009 Pearson Education, Inc. 4.6Lethal Alleles Represent Essential Genes 4.6.1Recessive Lethal Mutations
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Copyright © 2009 Pearson Education, Inc. Figure 4-4 Copyright © 2006 Pearson Prentice Hall, Inc. ?
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Copyright © 2009 Pearson Education, Inc. 4.6Lethal Alleles Represent Essential Genes 4.6.2Dominant Lethal Mutations
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Copyright © 2009 Pearson Education, Inc. 4.7Combinations of Two Gene Pairs With Two Modes of Inheritance Modify the 9:3:3:1 Ratio
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Copyright © 2009 Pearson Education, Inc. Figure 4.5
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Copyright © 2009 Pearson Education, Inc.
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4.8Phenotypes Are Often Affected by More Than One Gene 4.8.1Epistasis
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Copyright © 2009 Pearson Education, Inc. Figure 4.6
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Copyright © 2009 Pearson Education, Inc.
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Figure 4.7
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Copyright © 2009 Pearson Education, Inc. Figure 4.8
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Copyright © 2009 Pearson Education, Inc. Figure 4.9
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Copyright © 2009 Pearson Education, Inc. 4.9Complementation Analysis Can Determine if Two Mutations Causing a Similar Phenotype are Alleles
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Copyright © 2009 Pearson Education, Inc. Figure 4.11
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Copyright © 2009 Pearson Education, Inc. 4.10Expression of a Single Gene May Have Multiple Effects Pleiotropy
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Copyright © 2009 Pearson Education, Inc. 4.11X-Linkage Describes Genes on the X Chromosome 4.11.1X-Linkage in Drosophila
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Copyright © 2009 Pearson Education, Inc. Figure 4.12
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Copyright © 2009 Pearson Education, Inc. Figure 4.13
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Copyright © 2009 Pearson Education, Inc. 4.11X-Linkage Describes Genes on the X Chromosome 4.11.2X-Linkage in Humans
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Copyright © 2009 Pearson Education, Inc. Table 4.3
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Copyright © 2009 Pearson Education, Inc. Figure 4.14
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Copyright © 2009 Pearson Education, Inc. 4.12In Sex-Limited and Sex-Influenced Inheritance, an Individual’s Sex Influences the Phenotype
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Copyright © 2009 Pearson Education, Inc. Figure 4.15
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Copyright © 2009 Pearson Education, Inc. Figure 4.16
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Copyright © 2009 Pearson Education, Inc. 4.13Genetic Background and the Environment May Alter Phenotypic Expression 4.13.1Penetrance and Expressivity
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Copyright © 2009 Pearson Education, Inc. Figure 4.17
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Copyright © 2009 Pearson Education, Inc. 4.13Genetic Background and the Environment May Alter Phenotypic Expression 4.13.2Genetic Background: Suppression and Position Effects
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Copyright © 2009 Pearson Education, Inc. Figure 4.18
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Copyright © 2009 Pearson Education, Inc. 4.13Genetic Background and the Environment May Alter Phenotypic Expression 4.13.3Temperature Effects—An Introduction to Conditional Mutations
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Copyright © 2009 Pearson Education, Inc. Figure 4.19
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Copyright © 2009 Pearson Education, Inc. 4.13Genetic Background and the Environment May Alter Phenotypic Expression 4.13.4Nutritional Effects 4.13.5Onset of Genetic Expression 4.13.6Genetic Anticipation 4.13.7Genomic (Parental) Imprinting
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Copyright © 2009 Pearson Education, Inc.
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