1. ABC Mosquito Control Dr Kevin Gorman Oxitec Ltd, UK The views and opinions expressed in this presentation are those of the author and do not necessarily reflect the official policy or position of WSAID, The Miami Science Museum or any agency in Florida or the U.S. government. There have been limited field trials with this technique. Assumptions made within the presentation are not reflective of the position of WSAID, the Miami Science Museum, the Florida government or any U.S. government entity.

2. oxitec.com background What is the most dangerous animal on earth?

3. oxitec.com background A shark? A lion? A venomous snake?

4. oxitec.com background No - it’s the mosquito !

5. oxitec.com background Mosquitoes kill over 1 million people in the world every year…

6. oxitec.com background...they have a huge impact on human health

7. oxitec.com background Mosquito borne diseases:

8. oxitec.com background Mosquito borne diseases: Malaria

9. oxitec.com background Mosquito borne diseases: Dengue

10. oxitec.com background Mosquito borne diseases: Yellow fever

11. oxitec.com background Mosquito borne diseases: Chikungunya

12. oxitec.com background Mosquito borne diseases: Japanese encephalitis

13. oxitec.com background Mosquito borne diseases: and many more!

14. oxitec.com the problem So how do we usually control mosquitoes?

15. oxitec.com the problem We put insecticides in the water

16. oxitec.com the problem …and spray chemicals in the air

17. oxitec.com the problem We spray some more …

18. oxitec.com the problem and some more… Photo courtesy of Nathan Benn

19. oxitec.com the problem …but Dengue is still increasing!

20. oxitec.com the problem 2.5 billion people in the world are at risk

21. oxitec.com the problem No vaccine No medication

22. oxitec.com the solution We CAN do better… …a solution is ready

23. oxitec.com the solution We can use ABC

24. oxitec.com the solution Autocidal Biological Control The pest controls itself!

25. oxitec.com the solution Male mosquitoes do not bite or spread disease Only females do…

26. oxitec.com the solution We can genetically change males… …so they carry a lethal gene …and so we can recognise them TET

27. oxitec.com the solution Wild x Wild

28. oxitec.com the solution Transgenic x Wild

29. oxitec.com the solution More transgenic male mosquitoes means faster control Population No treatment Sterile males More sterile males Time

30. oxitec.com the solution It is effective

31. oxitec.com the solution Transgenic males mate only with wild female mosquitoes…of the same species …other species are unaffected

32. oxitec.com the solution It is effective and environmentally friendly

33. oxitec.com the solution A breakthrough in genetics providing a simple, effective and sustainable solution

34. Thank you! ABC– a novel approach to mosquito management