1. The Grand Challenge of Saving Brains November 2014

2. Area of focus is global health Funded by Government of Canada Funds innovators from developing countries and Canada Encourages Integrated Innovation Catalyzes impact at scale and sustainability Focuses on results: Saving and improving lives Bold Ideas. Big Impact. A Better World. Joseph L. Rotman (pictured top left); Peter A. Singer and the Honourable James Flaherty (pictured bottom right) at the Launch of Grand Challenges Canada on May 3, 2010 Overview

3. Saving Lives at Birth Global Mental HealthSaving Brains Stars in Global Health Grand Challenges in Global Health

4. CONFIDENTIAL The Problem Over 200 million children in developing countries are unable to fulfill their developmental potential Grantham-McGregor et al, Lancet 2007 Children’s health is a nation’s wealth: healthy child development is the foundation of a vital and productive society with a prosperous and sustainable future National Scientific Council on the Developing Child 2010 The Challenge To develop sustainable products, services and implementation models that protect, promote and nurture healthy child and brain development in the first 1000 days at scale with lasting impact on human capital in low resource settings. 4

5. CONFIDENTIAL Promote health and nutrition Protect against maltreatment and violence Provide enrichment and nurturing 5 For example: Support exclusive breastfeeding Treat micronutrient deficiency Care for babies born too soon Reduce exposure to environmental toxins For example: Coach parents to buffer stress Arm girls with negotiation skills For example: Treat maternal depression Integrate stimulation into child health Involve fathers in parenting Enhance quality of community nurseries Saving Brains Supporting bold ideas to improve early child development in low- and middle-income countries.

6. Focus Phase: Long-term Impact Round 1A, Re-enrolment grants: Launched May 2011 Funded 11 24-month projects, Total investment: $11.85M Round 1B, Economic grants: Launched October 2011 Funded 2 consortia, 18 Months Total investment: $4.66M Solution Phase: Scaling Round 2: Launched November 2012 10 24-mo seed projects: $2.7M 3 34-mo Transition-to-Scale projects: $6.0M Total investment: $8.7M Round 3: Launched October 2013 13 24-mo seed projects; TTS pending Includes 3 co-funded Brazilian grants Total investment to date: $3.5M Round 4: Proposals currently under peer review Saving Brains Investments + Stars in Global Health aligned to Saving Brains: $3.7M total investment, 34 innovations across 6 rounds 6 Total investments to date: $33.7M invested in 74 projects and a platform to accelerate progress against the challenge

7. Saving Brains in a sustainable manner, at scale, requires committed, engaged, aligned organizations who can bring their resources and expertise to bear. For example: Global partners to support innovations globally Regional partners to support innovations within regions of interest Implementation partners to inform current needs for innovation and rapidly take up innovations for impact at scale Corporate partners to support the scaling of specific innovations aligned with their core business 7 Saving Brains Partnership

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