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Microfluidics Copyright © 2012 Board of Trustees, University of Illinois. All rights reserved.
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2 Objectives Discover what microfluidics is Understand why it is important Make a simple microfluidic device Observe behavior of fluids at this scale
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3 What is it? Microfluidics- Precise control and manipulation of very small volumes of liquids Mm
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4 What is it? Microfluidics is often done in small channels on a device called a “Lab-on-a-chip”
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5 What is it? An alternative to traditional chemistry Why do we need an alternative?
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6 Traditional Chemistry Very large number of molecules –Even a drop of water contains about 10,000,000,000,000,000,000,000 molecules! It can be very expensive or very hard to get large number of molecules
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7 Traditional Chemistry Can be Hazardous –Hazards can spill or escape
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8 Traditional Chemistry Requires specialized equipment –Equipment expensive –Requires facilities to house –Wait for equipment to be available
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9 Traditional Chemistry Can take a long time –Time to create or isolate enough molecules –Equipment might not be immediately available
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10 Benefits of Microfluidics Traditional Laboratory Microfluidic “Lab-on- a-chip” CostOften very highInexpensive EquipmentSpecialized equipment Everything on chip Time to get results Significant timeQuick
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11 Why do it? Lets look at a problem and see if Microfluidics has a solution: Medicine in the developing world
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12 Medicine in the developing world Travel to facilities difficult
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13 Medicine in the developing world Long wait for care
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14 Medicine in the developing world Facilities often sparse or temporary
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15 Medicine in the developing world Equipment scarce
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16 Medicine in the developing world Power limited
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17 Medicine in the developing world Leads to primitive care
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18 Medicine in the developing world With microfluidics –Faster results –Inexpensive –Low power requirements –Portable, can travel to patients –Can perform complex diagnostic tests
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19 Applications Lab on a chip –Screening –Diagnostics –Analysis Biosensors DNA assays Fuel cells Microreactors Printing
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20 Applications Advanced manufacturing
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21 Center Research
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22 Center Research
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Master
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PDMS Mold Poured
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PDMS Mold Removed
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Top Plate Placed
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27 Petri Dish Puffy Paint Master PDMS Relief in PDMS
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28 Cross Section Perspective Puffy Paint Petri DishPDMS Channel Relief Plexi-glass Drilled Holes Plexi-glass
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29 PDMS Relief in PDMS Plexi-glass Drilled Holes Pipette
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30 Flow Regimes Imagine putting red liquid in one inlet and blue in the other. What immerges?
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31 Flow Regimes Laminar FlowTurbulent flow Channel size Flow Speed Viscosity SmallLarge FastSlow HighLow
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32 Which flow regime? What happens when you pour red liquid into one side and blue into another of a “Y” junction?
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