1. PROspective Multicenter Imaging Study for Evaluation of Chest Pain

2. How to get your site activated for PROMISE: Start-up Components n PROMISE Survey n Site Selection Visit by phone n Regulatory Documents n Contract and Budget n Diagnostic Testing Coordinating Center (DTCC) Approval n Training

3. Site Activation Flow DCRI Identifies Interested Sites Site Activation Process Regulatory Documents/ Approval Regulatory Documents/ Approval Contract/Budget Training Diagnostic Testing Activation TRIAD installation and test data transfer ACRIN TRIAD installation and test data transfer ACRIN Technical Evaluation MGH Core Lab Technical Evaluation MGH Core Lab CTA Case Review MGH Core Lab CTA Case Review MGH Core Lab 3

4. How to get your site activated for PROMISE: Survey and Site Selection n PROMISE Survey should already be complete n Sites that haven’t worked with DCRI in the recent past may get a Site Selection visit by phone

5. How to get your site activated for PROMISE: Regulatory Documents n Clinical Coordinating Center (CCC) Site Start- up Group - DCRI n CCC Project Team n Central IRB vs. Local IRB

6. How to get your site activated for PROMISE: Contract and Budget n CCC Site Start-up Group n DCRI Legal Department

7. How to get your site activated for PROMISE: DTCC Approval n Technical Evaluation – MGH n TRIAD Installation and Test Data Transfers – ACRIN n CTA Reader Case Review – MGH n DTCC is holding separate site activation calls to assist sites through this process

8. How to get your site activated for PROMISE: Training n Investigator Meeting n Webcasts l Protocol training l InForm training n Site Initiation Visits

9. https//:www.promisetrial.org

10. How to get your site activated for PROMISE: Contact Info – CCC Project Team Jerry Kirchner – Project Leader ph: 919-668-7818 email: jerry.kirchner@duke.edu jerry.kirchner@duke.edu Julie Randolph – Project Leader ph: 919-668-8769 email: julie.randolph@duke.edu julie.randolph@duke.edu Karen Cook – Lead CRA ph: 608-838-0490 email: karen.mcook@duke.edu karen.mcook@duke.edu Elizabeth Polisson – Clinical Lead CRA ph: 919-668-8603 email: elizabeth.polisson@duke.edu elizabeth.polisson@duke.edu Carrie Elliott – Clinical Lead CRA ph: 919-668-8021 email: carrie.elliott@duke.edu carrie.elliott@duke.edu

11. How to get your site activated for PROMISE: Contact Info – CCC Project Team (continued) Alice Edwards- CRA ph: 714-694-0743 email: alice.edwards@duke.edu alice.edwards@duke.edu Alex Hammett- CRA ph: 919-668-7094 email: alex.hammett@duke.edu alex.hammett@duke.edu Serena Mika- CRA ph: 919-668-8022 email: serena.mika@duke.edu serena.mika@duke.edu Sonya Sherer- CRA ph: 919-668-8533 email: sonya.sherer@duke.edu sonya.sherer@duke.edu Tonya McCoy-CRA Ph: 919-668-8258 email: tonya.mccoy@duke.edu tonya.mccoy@duke.edu

12. How to get your site activated for PROMISE: Contact Info – CCC Site Start-up Team Jennifer Peterson – Clinical Trial Manager ph: 919-668-4683 email: jennifer.peterson@duke.edu jennifer.peterson@duke.edu Dana Moore – Coordination Manager ph: 919-668-8894 email: dana.moore@duke.edu dana.moore@duke.edu Amber Brock – SSS ph: 919-668-8767 email: amber.brock@duke.edu amber.brock@duke.edu Kenasha Johnson – SSS ph: 919-668-8287 email: kenasha.johnson@duke.edu kenasha.johnson@duke.edu

13. How to get your site activated for PROMISE: Contact Info – CCC Site Start-up Team (continued) Chris Meade – SSS ph: 919-668-8262 email: chris.meade@duke.edu chris.meade@duke.edu LaChanda Reams – SSS ph: 919-668-8560 email: lachanda.reams@duke.edu lachanda.reams@duke.edu Laura Edgerton – SSS ph: 919-668-8320 email: laura.edgerton@duke.edu laura.edgerton@duke.edu Scott Acker – SSS ph: 919-668-8983 email: scott.acker@duke.edu scott.acker@duke.edu

14. How to get your site activated for PROMISE: Contact Info – DTCC Dr. Udo Hoffmann- Principal Investigator Ph: 617-726-1255 email: uhoffmann@partners.org uhoffmann@partners.org Nathan Sciortino- Project Manager ph: 617-643-5308 email: nsciortino@partners.org nsciortino@partners.org Erin Corsini- CRA ph: 617-643-0249 email: ecorsini@partners.org ecorsini@partners.org Kristen Salvaggio- CRA ph: 617-643-0244 email: ksalvaggio@partners.org ksalvaggio@partners.org

15. How to get your site activated for PROMISE: Contact Info – ACRIN Heather Polley- ACRIN Project Manager ph: 215-574-3245 email: hpolley@acr-arrs.org hpolley@acr-arrs.org Aimee Jordan- Echocardiography and ECGs ph: 215-940-8839 email: ajordan-t@acr-arrs.orgajordan-t@acr-arrs.org Dena Flamini- CCTA and Cardiac Catheterization Ph: 215-940-8880 email: dflamini@acr-arrs.org dflamini@acr-arrs.org Adam Opanowski- Nuclear Medicine (Nuclear Imaging) Ph: 215-940-8890 email: aopanowski@acr-arrs.org aopanowski@acr-arrs.org