1. Gene SymbolGene DescriptionFold Lna21-SP21-S RP2retinitis pigmentosa 2 (X-linked recessive)1.3-1.6 DDAH1dimethylarginine dimethylaminohydrolase 11.4-1.5 PM20D2peptidase M20 domain containing 21.2-1.5 RAD51AP1RAD51 associated protein 11.2-1.5 PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 1.3-1.5 ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 11.4-1.5 FAM36Afamily with sequence similarity 36, member A1.4-1.4 FAM3Cfamily with sequence similarity 3, member C1.2-1.4 CCNG1cyclin G11.3-1.4 FAM3Cfamily with sequence similarity 3, member C1.2-1.4 ALG10B asparagine-linked glycosylation 10 homolog B (yeast, alpha-1,2-glucosyltransferase) 1.3-1.4 APAF1apoptotic peptidase activating factor 11.6-1.4 MAMLD1mastermind-like domain containing 11.2-1.4 ARHGAP19Rho GTPase activating protein 191.2-1.4 ZNF826zinc finger protein 8261.2-1.4 RNF103ring finger protein 1031.2-1.3 SLC17A5 solute carrier family 17 (anion/sugar transporter), member 5 1.5-1.3 CEP97centrosomal protein 97kDa1.5-1.3 LEPREL1leprecan-like 11.3-1.3 SASS6spindle assembly 6 homolog (C. elegans)1.3-1.3 ZDHHC2zinc finger, DHHC-type containing 21.2-1.3 PRTFDC1phosphoribosyl transferase domain containing 11.4-1.3 FOXN3forkhead box N31.4-1.3 CCR7chemokine (C-C motif) receptor 71.3-1.3 E2F3E2F transcription factor 31.4-1.3 C9orf100chromosome 9 open reading frame 1001.3-1.3 IL1RAPinterleukin 1 receptor accessory protein1.4-1.3 BVESblood vessel epicardial substance1.9-1.2 FAM13A1family with sequence similarity 13, member A11.3-1.2 SGEF Src homology 3 domain-containing guanine nucleotide exchange factor 1.4-1.2 NCAPD3non-SMC condensin II complex, subunit D31.2-1.2 FAM63Bfamily with sequence similarity 63, member B1.4-1.2 PRICKLE2prickle homolog 2 (Drosophila)1.3-1.2 COL4A1collagen, type IV, alpha 12.2-1.2 RBMS3RNA binding motif, single stranded interacting protein1.2-1.2 KIAA1333 1.2-1.2 PSRC1proline/serine-rich coiled-coil 11.3-1.2 MORC4MORC family CW-type zinc finger 41.2-1.2 Table S2: List of Additional predicted targets based on overexpression and knockdown of miR-21 in keratinocytes

2. Gene SymbolGene DescriptionFold Lna21-SP21-S TGFBR2transforming growth factor, beta receptor II (70/80kDa)1.2-1.2 E2F8E2F transcription factor 81.3-1.6 KLHL15kelch-like 15 (Drosophila)1.8-1.6 C4orf21chromosome 4 open reading frame 211.3-1.5 C1orf112chromosome 1 open reading frame 1121.2-1.5 DNAJC19DnaJ (Hsp40) homolog, subfamily C, member 191.4-1.4 IL12RB2interleukin 12 receptor, beta 21.5-1.4 LRRCC1leucine rich repeat and coiled-coil domain containing 11.2-1.3 TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 1.4-1.3 DZIP3DAZ interacting protein 3, zinc finger2.0-1.3 ORC3Lorigin recognition complex, subunit 3-like (yeast)1.3-1.3 SGOL2shugoshin-like 2 (S. pombe)1.3-1.3 FBXO9F-box protein 91.2-1.3 WDR67WD repeat domain 671.2-1.3 NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12 1.3-1.3 ALG6 asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase) 1.4-1.3 FAM73Afamily with sequence similarity 73, member A1.2-1.2 ZNF507zinc finger protein 5071.3-1.2 KIF14kinesin family member 141.2-1.2 HMMRhyaluronan-mediated motility receptor (RHAMM)1.2-1.2 TMEM19transmembrane protein 191.5-1.2 LHFPlipoma HMGIC fusion partner1.3-1.2 RPGRIP1LRPGRIP1-like1.3-1.2 GTSE1G-2 and S-phase expressed 11.2-1.2 CA13carbonic anhydrase XIII1.3-1.2 CKAP2cytoskeleton associated protein 21.4-1.2 TBC1D19TBC1 domain family, member 191.2-1.2 TMEM14Atransmembrane protein 14A1.4-1.2 ARID2AT rich interactive domain 2 (ARID, RFX-like)1.2-1.2 WDR7WD repeat domain 71.3-1.2 SETMARSET domain and mariner transposase fusion gene1.3-1.2 PRKD3protein kinase D31.3-1.2 Table S2: List of Additional predicted targets based on overexpression and knockdown of miR-21 in keratinocytes