1. An Overview of the Research Institute 2012-13 Prof Alicia El Haj Director, Institute for Science & Technology in Medicine, Keele University

2. Keele University A campus-based university located in the West Midlands of England, offering dual-honours degrees and research in science, social science and humanities. Founded as a University College in 1949, it received its Royal Charter in 1962. www.keele.ac.uk

3. Research Institute for Science & Technology in Medicine (ISTM) Guy Hilton Research Centre RJ&AH Orthopaedic Hospital Keele Medical School University Hospital of North Staffordshire (PFI development) School of Life Sciences A multidisciplinary Institute formed in 2006 to underpin the new Medical School established between Keele and Manchester Universities ISTM brings together dispersed clinical and laboratory-based researchers from different departments and cultures.

4. Facilitating Biomedical Research ISTM brings together clinicians and bio-scientists across four hospital sites and the Keele campus: University Hospital of North Staffordshire, Hartshill, Stoke-on- Trent The Haywood Hospital, Burslem, Stoke-on-Trent Robert Jones & Agnes Hunt Orthopaedic Hospital, Oswestry Leighton Hospital, Crewe School of Medicine School of Pharmacy School of Health & Rehabilitation School of Life Sciences School of Computing & Mathematics School of Chemistry & Physics ISTM Away Day 2012

5. Potential Clinical application Basic science Cell biology/ Physics/ Biological Chemistry Bioengineering/ Imaging/ In vitro/ In vivo modelling “bench to bedside” Translational Research Clinical Trial Industrial Partnership Industrial Partnership

6. ISTM - Current Staff 88 full members: – Professors: 27 – Readers, Senior Lecturers, Clinical Lecturers: 40 – Lecturers: 18 – Research Fellows: 3 >25 NHS clinicians run clinical trials through ISTM 9 affiliated members from other Keele RI’s Key chair appointments of senior clinical/non clinical academics to expand capacity A large percentage of career-young researchers in the Medical and Pharmacy Schools

7. ISTM - Directors Director Prof Alicia El Haj Deputy Director Clinical co-Director Prof Paul EgglestonProf Simon Davies Director of Postgraduate Studies Prof Trevor Greenhough

8. ISTM – Scientific themes 2012 review of groupings underway Bioengineering & Therapeutics Clinical & Diagnostic Science Infection, Inflammation & Immunity (incorporating CAEP, the Centre for Applied Entomology & Parasitology) Neuroscience & Human Metabolism

9. Bioengineering & Therapeutics Theme leaders: Prof Alicia El Haj Prof James Richardson Cellular phenomena and cellular therapies for clinical applications e.g. Autologous treatments, e.g. knee cartilage Surgical repair, e.g. biomagnetic cell targeting Magnetism and magnetic materials techniques for biomedical applications, e.g. in the brain. ISTM is a European Centre of Excellence in Tissue Engineering.

10. Clinical & Diagnostic Science Theme leaders: Prof Gwyn Williams Prof Simon Davies Interaction between bioscientists, engineers, physicists, chemists and clinicians e.g. Molecular epidemiology and tumorigenesis Apoptosis (programmed cell death) Structural biology of the innate immune response Rheumatic and inflammatory diseases Breath analysis – monitoring and diagnosis ISTM has a dedicated Human Genomics facility

11. Infection, Inflammation & Immunity Incorporating the Centre for Applied Entomology and Parasitology (CAEP) Theme leader: Prof Gordon Hamilton Molecular approaches to control of insect vector-borne disease Malaria, mosquitoes and man Leishmania, sandflies and man Chemical ecology of insect communication Fish parasitology & comparative immunology CAEP is an internationally recognised centre with links to North and South America, Africa, Asia and Europe.

12. Neuroscience & Human Metabolism Theme leaders: Dr David Furness Prof Clive Hawkins Multidisciplinary studies of neuroscience, neurological and metabolic disorders Cellular and tissue engineering to restore damaged areas of the nervous system Clinical studies of multiple sclerosis and stroke Sensory neurobiology and plasticity Cardiovascular disease and its treatment

13. ISTM - Activity Metrics Manages ~185 live research grants and trials Receives £5m / year income, incl £3.8m in grants Applies for ~150 new research grants / year Outputs ~280 peer-reviewed publications / year RAE2008: 90% of staff rated of international quality in UoA 25 General Engineering REF2014: UoA 15 General Engineering UoA 3 Allied Health Professions UoA 5 Biological Sciences Potentially 50-60 academics submitted

14. ISTM Current Major Funding Sources Grant income forecast : ~ £4.5 million +

15. ISTM – Training Researchers Mentoring early-career lecturers and fellows Research fellows transition to independence ~35 research assistants and technical staff Support : eg Keele ACORN studentships, 3ME Initiative, MRC Centenary Awards, HEFCE Capital Equipment funds

16. International links to ISTM China, Malaysia, Brazil, India, Saudi Arabia Masters level PhD / MPhil Researcher exchanges Funded programmes – eg MRC African Leaders grant, HYANJI SCAFFOLD, NEMO, MagNETicFUN, Fellowships

17. ISTM - Enterprise Activities Industrial collaborations, eg: – MRC and BBSRC CASE studentships – European joint projects involving SMEs Contract research with UK / European industry: – 3M Healthcare Abbott Laboratories AstraZeneca Biogen Bose Corporation - Enduratec Bristol Myers Squibb Cellon SA ConMed Cordis Endovascular GlaxoSmithKline GW Pharma Merck Sharp & Dohme Novartis Oxitec PepTcell Pfizer Smith & Nephew Surgicraft Syngenta Teva Weleda AG Wella AG Wyeth Research Zimmer Licensing of IP Spin off companies from ISTM: – NanoTherics Mica Biosystems Nuovoprobe

18. ISTM web pages and contacts: Director: Prof Alicia El Haj +44 (0)1782 554605 a.j.el.haj@keele.ac.uk PA to Director: Paula Marsh +44 (0)1782 554253 p.marsh@keele.ac.uk RI Manager: Mark Smith +44 (0)1782 555234 m.e.smith@keele.ac.uk m.e.smith@keele.ac.uk Facililties & Administration Manager: Jeanette Forrester +44 (0)1782 675380 j.forrester@keele.ac.uk j.forrester@keele.ac.uk www.keele.ac.uk/istm/